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Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital
Although medicine acceptability is likely to have a significant impact on the patient’s adherence in pediatrics and therefore on therapy success, there is still little data even for common therapeutic areas. For analgesics/antipyretics, healthcare professionals face a wide variety of products and ne...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879646/ https://www.ncbi.nlm.nih.gov/pubmed/35214070 http://dx.doi.org/10.3390/pharmaceutics14020337 |
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author | Klingmann, Viviane Vallet, Thibault Münch, Juliane Stegemann, Robin Wolters, Lena Bosse, Hans-Martin Ruiz, Fabrice |
author_facet | Klingmann, Viviane Vallet, Thibault Münch, Juliane Stegemann, Robin Wolters, Lena Bosse, Hans-Martin Ruiz, Fabrice |
author_sort | Klingmann, Viviane |
collection | PubMed |
description | Although medicine acceptability is likely to have a significant impact on the patient’s adherence in pediatrics and therefore on therapy success, there is still little data even for common therapeutic areas. For analgesics/antipyretics, healthcare professionals face a wide variety of products and need knowledge to select the best adapted product for each patient. We investigated acceptability of those products most used at the University Children’s Hospital Düsseldorf, Germany. Based on 180 real-life observer reports of medicine intake, we used the acceptability reference framework to score acceptability of six distinct medicines. Both ibuprofen and paracetamol tablets, mainly used in adolescents, were positively accepted. This was not the case for the solution for injection of metamizole sodium. Regarding syrups, mainly used in children under 6 years of age, ibuprofen flavored with strawberry and provided with an oral syringe was positively accepted, while paracetamol flavored with orange and provided with a measuring cup was not. Suppository appeared to be an alternative to oral liquids in infants and toddlers with palatability and administration issues. Differences appeared to be driven by dosage forms and formulations. These findings improve knowledge on acceptability drivers and might help formulating and prescribing better medicines for children. |
format | Online Article Text |
id | pubmed-8879646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88796462022-02-26 Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital Klingmann, Viviane Vallet, Thibault Münch, Juliane Stegemann, Robin Wolters, Lena Bosse, Hans-Martin Ruiz, Fabrice Pharmaceutics Article Although medicine acceptability is likely to have a significant impact on the patient’s adherence in pediatrics and therefore on therapy success, there is still little data even for common therapeutic areas. For analgesics/antipyretics, healthcare professionals face a wide variety of products and need knowledge to select the best adapted product for each patient. We investigated acceptability of those products most used at the University Children’s Hospital Düsseldorf, Germany. Based on 180 real-life observer reports of medicine intake, we used the acceptability reference framework to score acceptability of six distinct medicines. Both ibuprofen and paracetamol tablets, mainly used in adolescents, were positively accepted. This was not the case for the solution for injection of metamizole sodium. Regarding syrups, mainly used in children under 6 years of age, ibuprofen flavored with strawberry and provided with an oral syringe was positively accepted, while paracetamol flavored with orange and provided with a measuring cup was not. Suppository appeared to be an alternative to oral liquids in infants and toddlers with palatability and administration issues. Differences appeared to be driven by dosage forms and formulations. These findings improve knowledge on acceptability drivers and might help formulating and prescribing better medicines for children. MDPI 2022-01-31 /pmc/articles/PMC8879646/ /pubmed/35214070 http://dx.doi.org/10.3390/pharmaceutics14020337 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Klingmann, Viviane Vallet, Thibault Münch, Juliane Stegemann, Robin Wolters, Lena Bosse, Hans-Martin Ruiz, Fabrice Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital |
title | Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital |
title_full | Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital |
title_fullStr | Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital |
title_full_unstemmed | Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital |
title_short | Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital |
title_sort | dosage forms suitability in pediatrics: acceptability of analgesics and antipyretics in a german hospital |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879646/ https://www.ncbi.nlm.nih.gov/pubmed/35214070 http://dx.doi.org/10.3390/pharmaceutics14020337 |
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