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Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital

Although medicine acceptability is likely to have a significant impact on the patient’s adherence in pediatrics and therefore on therapy success, there is still little data even for common therapeutic areas. For analgesics/antipyretics, healthcare professionals face a wide variety of products and ne...

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Autores principales: Klingmann, Viviane, Vallet, Thibault, Münch, Juliane, Stegemann, Robin, Wolters, Lena, Bosse, Hans-Martin, Ruiz, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879646/
https://www.ncbi.nlm.nih.gov/pubmed/35214070
http://dx.doi.org/10.3390/pharmaceutics14020337
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author Klingmann, Viviane
Vallet, Thibault
Münch, Juliane
Stegemann, Robin
Wolters, Lena
Bosse, Hans-Martin
Ruiz, Fabrice
author_facet Klingmann, Viviane
Vallet, Thibault
Münch, Juliane
Stegemann, Robin
Wolters, Lena
Bosse, Hans-Martin
Ruiz, Fabrice
author_sort Klingmann, Viviane
collection PubMed
description Although medicine acceptability is likely to have a significant impact on the patient’s adherence in pediatrics and therefore on therapy success, there is still little data even for common therapeutic areas. For analgesics/antipyretics, healthcare professionals face a wide variety of products and need knowledge to select the best adapted product for each patient. We investigated acceptability of those products most used at the University Children’s Hospital Düsseldorf, Germany. Based on 180 real-life observer reports of medicine intake, we used the acceptability reference framework to score acceptability of six distinct medicines. Both ibuprofen and paracetamol tablets, mainly used in adolescents, were positively accepted. This was not the case for the solution for injection of metamizole sodium. Regarding syrups, mainly used in children under 6 years of age, ibuprofen flavored with strawberry and provided with an oral syringe was positively accepted, while paracetamol flavored with orange and provided with a measuring cup was not. Suppository appeared to be an alternative to oral liquids in infants and toddlers with palatability and administration issues. Differences appeared to be driven by dosage forms and formulations. These findings improve knowledge on acceptability drivers and might help formulating and prescribing better medicines for children.
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spelling pubmed-88796462022-02-26 Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital Klingmann, Viviane Vallet, Thibault Münch, Juliane Stegemann, Robin Wolters, Lena Bosse, Hans-Martin Ruiz, Fabrice Pharmaceutics Article Although medicine acceptability is likely to have a significant impact on the patient’s adherence in pediatrics and therefore on therapy success, there is still little data even for common therapeutic areas. For analgesics/antipyretics, healthcare professionals face a wide variety of products and need knowledge to select the best adapted product for each patient. We investigated acceptability of those products most used at the University Children’s Hospital Düsseldorf, Germany. Based on 180 real-life observer reports of medicine intake, we used the acceptability reference framework to score acceptability of six distinct medicines. Both ibuprofen and paracetamol tablets, mainly used in adolescents, were positively accepted. This was not the case for the solution for injection of metamizole sodium. Regarding syrups, mainly used in children under 6 years of age, ibuprofen flavored with strawberry and provided with an oral syringe was positively accepted, while paracetamol flavored with orange and provided with a measuring cup was not. Suppository appeared to be an alternative to oral liquids in infants and toddlers with palatability and administration issues. Differences appeared to be driven by dosage forms and formulations. These findings improve knowledge on acceptability drivers and might help formulating and prescribing better medicines for children. MDPI 2022-01-31 /pmc/articles/PMC8879646/ /pubmed/35214070 http://dx.doi.org/10.3390/pharmaceutics14020337 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Klingmann, Viviane
Vallet, Thibault
Münch, Juliane
Stegemann, Robin
Wolters, Lena
Bosse, Hans-Martin
Ruiz, Fabrice
Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital
title Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital
title_full Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital
title_fullStr Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital
title_full_unstemmed Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital
title_short Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German Hospital
title_sort dosage forms suitability in pediatrics: acceptability of analgesics and antipyretics in a german hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879646/
https://www.ncbi.nlm.nih.gov/pubmed/35214070
http://dx.doi.org/10.3390/pharmaceutics14020337
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