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Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder
Studies have demonstrated that chronic consumption of abused drugs induces alterations in several proteins that regulate metabolism. For instance, methamphetamine exposure reduces glucose levels. Fatty and amino acid levels were altered in groups exposed to abused drugs. Therefore, in our study, we...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879674/ https://www.ncbi.nlm.nih.gov/pubmed/35208253 http://dx.doi.org/10.3390/metabo12020179 |
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author | Alasmari, Fawaz Assiri, Mohammed A. Ahamad, Syed Rizwan Aljumayi, Sahar R. Alotaibi, Wedad H. Alhamdan, Majd M. Alhazzani, Khalid Alharbi, Metab Alqahtani, Faleh Alasmari, Abdullah F. |
author_facet | Alasmari, Fawaz Assiri, Mohammed A. Ahamad, Syed Rizwan Aljumayi, Sahar R. Alotaibi, Wedad H. Alhamdan, Majd M. Alhazzani, Khalid Alharbi, Metab Alqahtani, Faleh Alasmari, Abdullah F. |
author_sort | Alasmari, Fawaz |
collection | PubMed |
description | Studies have demonstrated that chronic consumption of abused drugs induces alterations in several proteins that regulate metabolism. For instance, methamphetamine exposure reduces glucose levels. Fatty and amino acid levels were altered in groups exposed to abused drugs. Therefore, in our study, we investigated the serum metabolomic profile of patients diagnosed with cannabis and/or amphetamine use disorders. Blood was obtained from subjects (control, amphetamine, and cannabis). Detection of serum metabolites was performed using gas chromatography. The ratio peak areas for metabolites were analyzed across the three groups. Both cannabis and amphetamine groups showed higher d-erythrotetrafuranose, octadecanoic acid, hexadecenoic acid, trans-9-octadecanoic acid, lactic acid and methyl thio hydantoin metabolites compared with the control group. Moreover, cannabis patients were found to possess higher glycine, 9,12 octadecanoic acid malonic acid, phosphoric acid and prostaglandin F1a than controls. Our analysis showed that the identified metabolic profile of cannabis or amphetamine use disorder patients was different than control group. Our data indicated that chronic exposure to cannabis or amphetamine dysregulated metabolites in the serum. Future studies are warranted to explore the effects of these abused drugs on the metabolic proteins. |
format | Online Article Text |
id | pubmed-8879674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88796742022-02-26 Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder Alasmari, Fawaz Assiri, Mohammed A. Ahamad, Syed Rizwan Aljumayi, Sahar R. Alotaibi, Wedad H. Alhamdan, Majd M. Alhazzani, Khalid Alharbi, Metab Alqahtani, Faleh Alasmari, Abdullah F. Metabolites Article Studies have demonstrated that chronic consumption of abused drugs induces alterations in several proteins that regulate metabolism. For instance, methamphetamine exposure reduces glucose levels. Fatty and amino acid levels were altered in groups exposed to abused drugs. Therefore, in our study, we investigated the serum metabolomic profile of patients diagnosed with cannabis and/or amphetamine use disorders. Blood was obtained from subjects (control, amphetamine, and cannabis). Detection of serum metabolites was performed using gas chromatography. The ratio peak areas for metabolites were analyzed across the three groups. Both cannabis and amphetamine groups showed higher d-erythrotetrafuranose, octadecanoic acid, hexadecenoic acid, trans-9-octadecanoic acid, lactic acid and methyl thio hydantoin metabolites compared with the control group. Moreover, cannabis patients were found to possess higher glycine, 9,12 octadecanoic acid malonic acid, phosphoric acid and prostaglandin F1a than controls. Our analysis showed that the identified metabolic profile of cannabis or amphetamine use disorder patients was different than control group. Our data indicated that chronic exposure to cannabis or amphetamine dysregulated metabolites in the serum. Future studies are warranted to explore the effects of these abused drugs on the metabolic proteins. MDPI 2022-02-14 /pmc/articles/PMC8879674/ /pubmed/35208253 http://dx.doi.org/10.3390/metabo12020179 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alasmari, Fawaz Assiri, Mohammed A. Ahamad, Syed Rizwan Aljumayi, Sahar R. Alotaibi, Wedad H. Alhamdan, Majd M. Alhazzani, Khalid Alharbi, Metab Alqahtani, Faleh Alasmari, Abdullah F. Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder |
title | Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder |
title_full | Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder |
title_fullStr | Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder |
title_full_unstemmed | Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder |
title_short | Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder |
title_sort | serum metabolomic analysis of male patients with cannabis or amphetamine use disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879674/ https://www.ncbi.nlm.nih.gov/pubmed/35208253 http://dx.doi.org/10.3390/metabo12020179 |
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