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Mortality Predictive Value of the C(2)HEST Score in Elderly Subjects with COVID-19—A Subanalysis of the COLOS Study
Senility has been identified among the strongest risk predictors for unfavorable COVID-19-outcome. However, even in the elderly population, the clinical course of infection in individual patients remains unpredictable. Hence, there is an urgent need for developing a simple tool predicting adverse CO...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879688/ https://www.ncbi.nlm.nih.gov/pubmed/35207272 http://dx.doi.org/10.3390/jcm11040992 |
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author | Rola, Piotr Doroszko, Adrian Trocha, Małgorzata Giniewicz, Katarzyna Kujawa, Krzysztof Skarupski, Marek Gawryś, Jakub Matys, Tomasz Szahidewicz-Krupska, Ewa Gajecki, Damian Adamik, Barbara Kaliszewski, Krzysztof Kilis-Pstrusinska, Katarzyna Letachowicz, Krzysztof Matera-Witkiewicz, Agnieszka Pomorski, Michał Protasiewicz, Marcin Majchrzak, Konrad Sokołowski, Janusz Jankowska, Ewa Anita Madziarska, Katarzyna |
author_facet | Rola, Piotr Doroszko, Adrian Trocha, Małgorzata Giniewicz, Katarzyna Kujawa, Krzysztof Skarupski, Marek Gawryś, Jakub Matys, Tomasz Szahidewicz-Krupska, Ewa Gajecki, Damian Adamik, Barbara Kaliszewski, Krzysztof Kilis-Pstrusinska, Katarzyna Letachowicz, Krzysztof Matera-Witkiewicz, Agnieszka Pomorski, Michał Protasiewicz, Marcin Majchrzak, Konrad Sokołowski, Janusz Jankowska, Ewa Anita Madziarska, Katarzyna |
author_sort | Rola, Piotr |
collection | PubMed |
description | Senility has been identified among the strongest risk predictors for unfavorable COVID-19-outcome. However, even in the elderly population, the clinical course of infection in individual patients remains unpredictable. Hence, there is an urgent need for developing a simple tool predicting adverse COVID-19-outcomes. We assumed that the C2HEST-score could predict unfavorable clinical outcomes in the elderly subjects with COVID-19-subjects. Methods: We retrospectively analyzed 1047 medical records of patients at age > 65 years, hospitalized at the medical university center due to COVID-19. Subsequently, patients were divided into three categories depending on their C2HEST-score result. Results: We noticed significant differences in the in-hospital and 3-month and 6-month mortality-which was the highest in high-risk-C2HEST-stratum reaching 35.7%, 54.4%, and 65.9%, respectively. The medium-risk-stratum mortalities reached 24.1% 43.4%, and 57.6% and for low-risk-stratum 14.4%, 25.8%, and 39.2% respectively. In the C2HEST-score model, a change from the low to the medium category increased the probability of death intensity approximately two-times. Subsequently, transfer from the low-risk to the high-risk-stratum raised all-cause-death-intensity 2.7-times. Analysis of the secondary outcomes revealed that the C2HEST-score has predictive value for acute kidney injury, acute heart failure, and cardiogenic shock. Conclusions: C2HEST-score analysis on admission to the hospital may predict the mortality, acute kidney injury, and acute heart failure in elderly subjects with COVID-19. |
format | Online Article Text |
id | pubmed-8879688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88796882022-02-26 Mortality Predictive Value of the C(2)HEST Score in Elderly Subjects with COVID-19—A Subanalysis of the COLOS Study Rola, Piotr Doroszko, Adrian Trocha, Małgorzata Giniewicz, Katarzyna Kujawa, Krzysztof Skarupski, Marek Gawryś, Jakub Matys, Tomasz Szahidewicz-Krupska, Ewa Gajecki, Damian Adamik, Barbara Kaliszewski, Krzysztof Kilis-Pstrusinska, Katarzyna Letachowicz, Krzysztof Matera-Witkiewicz, Agnieszka Pomorski, Michał Protasiewicz, Marcin Majchrzak, Konrad Sokołowski, Janusz Jankowska, Ewa Anita Madziarska, Katarzyna J Clin Med Article Senility has been identified among the strongest risk predictors for unfavorable COVID-19-outcome. However, even in the elderly population, the clinical course of infection in individual patients remains unpredictable. Hence, there is an urgent need for developing a simple tool predicting adverse COVID-19-outcomes. We assumed that the C2HEST-score could predict unfavorable clinical outcomes in the elderly subjects with COVID-19-subjects. Methods: We retrospectively analyzed 1047 medical records of patients at age > 65 years, hospitalized at the medical university center due to COVID-19. Subsequently, patients were divided into three categories depending on their C2HEST-score result. Results: We noticed significant differences in the in-hospital and 3-month and 6-month mortality-which was the highest in high-risk-C2HEST-stratum reaching 35.7%, 54.4%, and 65.9%, respectively. The medium-risk-stratum mortalities reached 24.1% 43.4%, and 57.6% and for low-risk-stratum 14.4%, 25.8%, and 39.2% respectively. In the C2HEST-score model, a change from the low to the medium category increased the probability of death intensity approximately two-times. Subsequently, transfer from the low-risk to the high-risk-stratum raised all-cause-death-intensity 2.7-times. Analysis of the secondary outcomes revealed that the C2HEST-score has predictive value for acute kidney injury, acute heart failure, and cardiogenic shock. Conclusions: C2HEST-score analysis on admission to the hospital may predict the mortality, acute kidney injury, and acute heart failure in elderly subjects with COVID-19. MDPI 2022-02-14 /pmc/articles/PMC8879688/ /pubmed/35207272 http://dx.doi.org/10.3390/jcm11040992 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rola, Piotr Doroszko, Adrian Trocha, Małgorzata Giniewicz, Katarzyna Kujawa, Krzysztof Skarupski, Marek Gawryś, Jakub Matys, Tomasz Szahidewicz-Krupska, Ewa Gajecki, Damian Adamik, Barbara Kaliszewski, Krzysztof Kilis-Pstrusinska, Katarzyna Letachowicz, Krzysztof Matera-Witkiewicz, Agnieszka Pomorski, Michał Protasiewicz, Marcin Majchrzak, Konrad Sokołowski, Janusz Jankowska, Ewa Anita Madziarska, Katarzyna Mortality Predictive Value of the C(2)HEST Score in Elderly Subjects with COVID-19—A Subanalysis of the COLOS Study |
title | Mortality Predictive Value of the C(2)HEST Score in Elderly Subjects with COVID-19—A Subanalysis of the COLOS Study |
title_full | Mortality Predictive Value of the C(2)HEST Score in Elderly Subjects with COVID-19—A Subanalysis of the COLOS Study |
title_fullStr | Mortality Predictive Value of the C(2)HEST Score in Elderly Subjects with COVID-19—A Subanalysis of the COLOS Study |
title_full_unstemmed | Mortality Predictive Value of the C(2)HEST Score in Elderly Subjects with COVID-19—A Subanalysis of the COLOS Study |
title_short | Mortality Predictive Value of the C(2)HEST Score in Elderly Subjects with COVID-19—A Subanalysis of the COLOS Study |
title_sort | mortality predictive value of the c(2)hest score in elderly subjects with covid-19—a subanalysis of the colos study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879688/ https://www.ncbi.nlm.nih.gov/pubmed/35207272 http://dx.doi.org/10.3390/jcm11040992 |
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