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Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer

The aim of the report was to present the circulation of BVDV (bovine viral diarrhea virus) in the cattle population and determine the cause of the failure of vaccination failure leading to the birth of the PI (persistently infected) calf. The case study was carried out at the BVDV-free animal breedi...

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Autores principales: Klimowicz-Bodys, Małgorzata D., Polak, Mirosław P., Płoneczka-Janeczko, Katarzyna, Bagnicka, Emilia, Zbroja, Dominika, Rypuła, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879756/
https://www.ncbi.nlm.nih.gov/pubmed/35215904
http://dx.doi.org/10.3390/v14020311
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author Klimowicz-Bodys, Małgorzata D.
Polak, Mirosław P.
Płoneczka-Janeczko, Katarzyna
Bagnicka, Emilia
Zbroja, Dominika
Rypuła, Krzysztof
author_facet Klimowicz-Bodys, Małgorzata D.
Polak, Mirosław P.
Płoneczka-Janeczko, Katarzyna
Bagnicka, Emilia
Zbroja, Dominika
Rypuła, Krzysztof
author_sort Klimowicz-Bodys, Małgorzata D.
collection PubMed
description The aim of the report was to present the circulation of BVDV (bovine viral diarrhea virus) in the cattle population and determine the cause of the failure of vaccination failure leading to the birth of the PI (persistently infected) calf. The case study was carried out at the BVDV-free animal breeding center and cattle farm, where the vaccination program against BVDV was implemented in 2012, and each newly introduced animal was serologically and virologically tested for BVDV. In this case, a blood sample was taken from a 9-month-old breeding bull. Positive RT-PCR and negative ELISA serology results were obtained. The tests were repeated at 2-week intervals, and the results confirmed the presence of the virus and the absence of specific antibodies, i.e., persistent infection. Additionally, sequencing and phylogenetic analysis were performed, and the BVDV-1d subgenotype was detected. The results of this study showed that pregnant heifers and cows that are vaccinated multiple times with the killed vaccine containing BVDV-1a may not be fully protected against infection with other subgenotypes of BVDV, including their fetuses, which can become PI calves.
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spelling pubmed-88797562022-02-26 Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer Klimowicz-Bodys, Małgorzata D. Polak, Mirosław P. Płoneczka-Janeczko, Katarzyna Bagnicka, Emilia Zbroja, Dominika Rypuła, Krzysztof Viruses Case Report The aim of the report was to present the circulation of BVDV (bovine viral diarrhea virus) in the cattle population and determine the cause of the failure of vaccination failure leading to the birth of the PI (persistently infected) calf. The case study was carried out at the BVDV-free animal breeding center and cattle farm, where the vaccination program against BVDV was implemented in 2012, and each newly introduced animal was serologically and virologically tested for BVDV. In this case, a blood sample was taken from a 9-month-old breeding bull. Positive RT-PCR and negative ELISA serology results were obtained. The tests were repeated at 2-week intervals, and the results confirmed the presence of the virus and the absence of specific antibodies, i.e., persistent infection. Additionally, sequencing and phylogenetic analysis were performed, and the BVDV-1d subgenotype was detected. The results of this study showed that pregnant heifers and cows that are vaccinated multiple times with the killed vaccine containing BVDV-1a may not be fully protected against infection with other subgenotypes of BVDV, including their fetuses, which can become PI calves. MDPI 2022-02-02 /pmc/articles/PMC8879756/ /pubmed/35215904 http://dx.doi.org/10.3390/v14020311 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Klimowicz-Bodys, Małgorzata D.
Polak, Mirosław P.
Płoneczka-Janeczko, Katarzyna
Bagnicka, Emilia
Zbroja, Dominika
Rypuła, Krzysztof
Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer
title Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer
title_full Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer
title_fullStr Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer
title_full_unstemmed Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer
title_short Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer
title_sort lack of fetal protection against bovine viral diarrhea virus in a vaccinated heifer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879756/
https://www.ncbi.nlm.nih.gov/pubmed/35215904
http://dx.doi.org/10.3390/v14020311
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