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Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer
The aim of the report was to present the circulation of BVDV (bovine viral diarrhea virus) in the cattle population and determine the cause of the failure of vaccination failure leading to the birth of the PI (persistently infected) calf. The case study was carried out at the BVDV-free animal breedi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879756/ https://www.ncbi.nlm.nih.gov/pubmed/35215904 http://dx.doi.org/10.3390/v14020311 |
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author | Klimowicz-Bodys, Małgorzata D. Polak, Mirosław P. Płoneczka-Janeczko, Katarzyna Bagnicka, Emilia Zbroja, Dominika Rypuła, Krzysztof |
author_facet | Klimowicz-Bodys, Małgorzata D. Polak, Mirosław P. Płoneczka-Janeczko, Katarzyna Bagnicka, Emilia Zbroja, Dominika Rypuła, Krzysztof |
author_sort | Klimowicz-Bodys, Małgorzata D. |
collection | PubMed |
description | The aim of the report was to present the circulation of BVDV (bovine viral diarrhea virus) in the cattle population and determine the cause of the failure of vaccination failure leading to the birth of the PI (persistently infected) calf. The case study was carried out at the BVDV-free animal breeding center and cattle farm, where the vaccination program against BVDV was implemented in 2012, and each newly introduced animal was serologically and virologically tested for BVDV. In this case, a blood sample was taken from a 9-month-old breeding bull. Positive RT-PCR and negative ELISA serology results were obtained. The tests were repeated at 2-week intervals, and the results confirmed the presence of the virus and the absence of specific antibodies, i.e., persistent infection. Additionally, sequencing and phylogenetic analysis were performed, and the BVDV-1d subgenotype was detected. The results of this study showed that pregnant heifers and cows that are vaccinated multiple times with the killed vaccine containing BVDV-1a may not be fully protected against infection with other subgenotypes of BVDV, including their fetuses, which can become PI calves. |
format | Online Article Text |
id | pubmed-8879756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88797562022-02-26 Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer Klimowicz-Bodys, Małgorzata D. Polak, Mirosław P. Płoneczka-Janeczko, Katarzyna Bagnicka, Emilia Zbroja, Dominika Rypuła, Krzysztof Viruses Case Report The aim of the report was to present the circulation of BVDV (bovine viral diarrhea virus) in the cattle population and determine the cause of the failure of vaccination failure leading to the birth of the PI (persistently infected) calf. The case study was carried out at the BVDV-free animal breeding center and cattle farm, where the vaccination program against BVDV was implemented in 2012, and each newly introduced animal was serologically and virologically tested for BVDV. In this case, a blood sample was taken from a 9-month-old breeding bull. Positive RT-PCR and negative ELISA serology results were obtained. The tests were repeated at 2-week intervals, and the results confirmed the presence of the virus and the absence of specific antibodies, i.e., persistent infection. Additionally, sequencing and phylogenetic analysis were performed, and the BVDV-1d subgenotype was detected. The results of this study showed that pregnant heifers and cows that are vaccinated multiple times with the killed vaccine containing BVDV-1a may not be fully protected against infection with other subgenotypes of BVDV, including their fetuses, which can become PI calves. MDPI 2022-02-02 /pmc/articles/PMC8879756/ /pubmed/35215904 http://dx.doi.org/10.3390/v14020311 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Klimowicz-Bodys, Małgorzata D. Polak, Mirosław P. Płoneczka-Janeczko, Katarzyna Bagnicka, Emilia Zbroja, Dominika Rypuła, Krzysztof Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer |
title | Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer |
title_full | Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer |
title_fullStr | Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer |
title_full_unstemmed | Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer |
title_short | Lack of Fetal Protection against Bovine Viral Diarrhea Virus in a Vaccinated Heifer |
title_sort | lack of fetal protection against bovine viral diarrhea virus in a vaccinated heifer |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879756/ https://www.ncbi.nlm.nih.gov/pubmed/35215904 http://dx.doi.org/10.3390/v14020311 |
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