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Which Clusters of Metabolic Syndrome Are the Most Associated with Serum Uric Acid?

Background and Objectives: Metabolic syndrome is defined as three or more of five components; therefore, there are 16 possible different clusters of metabolic risk factors that are under one diagnosis of metabolic syndrome. In this study, we evaluated the different clusters of metabolic syndrome (Me...

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Autores principales: Mikolaitytė, Jurgita, Badarienė, Jolita, Puronaitė, Roma, Čypienė, Alma, Rutkauskienė, Irma, Dadonienė, Jolanta, Laucevičius, Aleksandras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879816/
https://www.ncbi.nlm.nih.gov/pubmed/35208620
http://dx.doi.org/10.3390/medicina58020297
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author Mikolaitytė, Jurgita
Badarienė, Jolita
Puronaitė, Roma
Čypienė, Alma
Rutkauskienė, Irma
Dadonienė, Jolanta
Laucevičius, Aleksandras
author_facet Mikolaitytė, Jurgita
Badarienė, Jolita
Puronaitė, Roma
Čypienė, Alma
Rutkauskienė, Irma
Dadonienė, Jolanta
Laucevičius, Aleksandras
author_sort Mikolaitytė, Jurgita
collection PubMed
description Background and Objectives: Metabolic syndrome is defined as three or more of five components; therefore, there are 16 possible different clusters of metabolic risk factors that are under one diagnosis of metabolic syndrome. In this study, we evaluated the different clusters of metabolic syndrome (MetS) across serum uric acid (SUA) quartiles and analyzed the association of these clusters with SUA levels, respectively, in both men and women. Materials and Methods: A total of 606 subjects were recruited to a cross-sectional study from the ongoing Lithuanian High Cardiovascular Risk primary prevention program (LitHiR). All of the study subjects were diagnosed with MetS (according to the 2005 National Cholesterol Education Program Adult Treatment Panel III MetS definition). Results: In the middle-aged population of patients with MetS living in Lithuania, a high proportion of hyperuricaemia was detected—35.5% (95% Cl 31.7% to 39.4%). For women possessing all five MetS components, the chances of having hyperuricaemia are 2.807 higher than for women with three risk factors (p < 0.001). However, men do not have a statistically significantly higher chance of having hyperuricaemia, depending on the number of MetS components in our population. Using multivariable models, the statistically significant chance of having hyperuricaemia was observed only in women possessing all five MetS components (OR = 2.386, p < 0.0001), compared to any other of 15 MetS clusters. After adjustment for age and sex, the chance of having hyperuricaemia for individuals with the cluster of all five MetS components, compared to any other of 15 MetS clusters, remained (OR = 1.982, p = 0.001). Also, a lower probability (OR = 0.653, p = 0.039) of having hyperuricaemia was observed for individuals having the combination of abnormal plasma glucose, blood pressure, and waist circumference. Conclusions: Patients with the clustering of all five metabolic syndrome components are at higher risk for having hyperuricaemia than patients with any other combination of MetS clusters. This risk is even higher for women. It could be beneficial for patients presented with all five MetS components to be screened for SUA concentration in the primary CVD prevention program.
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spelling pubmed-88798162022-02-26 Which Clusters of Metabolic Syndrome Are the Most Associated with Serum Uric Acid? Mikolaitytė, Jurgita Badarienė, Jolita Puronaitė, Roma Čypienė, Alma Rutkauskienė, Irma Dadonienė, Jolanta Laucevičius, Aleksandras Medicina (Kaunas) Article Background and Objectives: Metabolic syndrome is defined as three or more of five components; therefore, there are 16 possible different clusters of metabolic risk factors that are under one diagnosis of metabolic syndrome. In this study, we evaluated the different clusters of metabolic syndrome (MetS) across serum uric acid (SUA) quartiles and analyzed the association of these clusters with SUA levels, respectively, in both men and women. Materials and Methods: A total of 606 subjects were recruited to a cross-sectional study from the ongoing Lithuanian High Cardiovascular Risk primary prevention program (LitHiR). All of the study subjects were diagnosed with MetS (according to the 2005 National Cholesterol Education Program Adult Treatment Panel III MetS definition). Results: In the middle-aged population of patients with MetS living in Lithuania, a high proportion of hyperuricaemia was detected—35.5% (95% Cl 31.7% to 39.4%). For women possessing all five MetS components, the chances of having hyperuricaemia are 2.807 higher than for women with three risk factors (p < 0.001). However, men do not have a statistically significantly higher chance of having hyperuricaemia, depending on the number of MetS components in our population. Using multivariable models, the statistically significant chance of having hyperuricaemia was observed only in women possessing all five MetS components (OR = 2.386, p < 0.0001), compared to any other of 15 MetS clusters. After adjustment for age and sex, the chance of having hyperuricaemia for individuals with the cluster of all five MetS components, compared to any other of 15 MetS clusters, remained (OR = 1.982, p = 0.001). Also, a lower probability (OR = 0.653, p = 0.039) of having hyperuricaemia was observed for individuals having the combination of abnormal plasma glucose, blood pressure, and waist circumference. Conclusions: Patients with the clustering of all five metabolic syndrome components are at higher risk for having hyperuricaemia than patients with any other combination of MetS clusters. This risk is even higher for women. It could be beneficial for patients presented with all five MetS components to be screened for SUA concentration in the primary CVD prevention program. MDPI 2022-02-16 /pmc/articles/PMC8879816/ /pubmed/35208620 http://dx.doi.org/10.3390/medicina58020297 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mikolaitytė, Jurgita
Badarienė, Jolita
Puronaitė, Roma
Čypienė, Alma
Rutkauskienė, Irma
Dadonienė, Jolanta
Laucevičius, Aleksandras
Which Clusters of Metabolic Syndrome Are the Most Associated with Serum Uric Acid?
title Which Clusters of Metabolic Syndrome Are the Most Associated with Serum Uric Acid?
title_full Which Clusters of Metabolic Syndrome Are the Most Associated with Serum Uric Acid?
title_fullStr Which Clusters of Metabolic Syndrome Are the Most Associated with Serum Uric Acid?
title_full_unstemmed Which Clusters of Metabolic Syndrome Are the Most Associated with Serum Uric Acid?
title_short Which Clusters of Metabolic Syndrome Are the Most Associated with Serum Uric Acid?
title_sort which clusters of metabolic syndrome are the most associated with serum uric acid?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879816/
https://www.ncbi.nlm.nih.gov/pubmed/35208620
http://dx.doi.org/10.3390/medicina58020297
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