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Identification, Culture and Targeting of Cancer Stem Cells
Chemoresistance, tumor progression, and metastasis are features that are frequently seen in cancer that have been associated with cancer stem cells (CSCs). These cells are a promising target in the future of cancer therapy but remain largely unknown. Deregulation of pathways that govern stemness in...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879966/ https://www.ncbi.nlm.nih.gov/pubmed/35207472 http://dx.doi.org/10.3390/life12020184 |
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author | Herreros-Pomares, Alejandro |
author_facet | Herreros-Pomares, Alejandro |
author_sort | Herreros-Pomares, Alejandro |
collection | PubMed |
description | Chemoresistance, tumor progression, and metastasis are features that are frequently seen in cancer that have been associated with cancer stem cells (CSCs). These cells are a promising target in the future of cancer therapy but remain largely unknown. Deregulation of pathways that govern stemness in non-tumorigenic stem cells (SCs), such as Notch, Wnt, and Hedgehog pathways, has been described in CSC pathogenesis, but it is necessary to conduct further studies to discover potential new therapeutic targets. In addition, some markers for the identification and characterization of CSCs have been suggested, but the search for specific CSC markers in many cancer types is still under development. In addition, methods for CSC cultivation are also under development, with great heterogeneity existing in the protocols used. This review focuses on the most recent aspects of the identification, characterization, cultivation, and targeting of human CSCs, highlighting the advances achieved in the clinical implementation of therapies targeting CSCs and remarking those potential areas where more research is still required. |
format | Online Article Text |
id | pubmed-8879966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88799662022-02-26 Identification, Culture and Targeting of Cancer Stem Cells Herreros-Pomares, Alejandro Life (Basel) Review Chemoresistance, tumor progression, and metastasis are features that are frequently seen in cancer that have been associated with cancer stem cells (CSCs). These cells are a promising target in the future of cancer therapy but remain largely unknown. Deregulation of pathways that govern stemness in non-tumorigenic stem cells (SCs), such as Notch, Wnt, and Hedgehog pathways, has been described in CSC pathogenesis, but it is necessary to conduct further studies to discover potential new therapeutic targets. In addition, some markers for the identification and characterization of CSCs have been suggested, but the search for specific CSC markers in many cancer types is still under development. In addition, methods for CSC cultivation are also under development, with great heterogeneity existing in the protocols used. This review focuses on the most recent aspects of the identification, characterization, cultivation, and targeting of human CSCs, highlighting the advances achieved in the clinical implementation of therapies targeting CSCs and remarking those potential areas where more research is still required. MDPI 2022-01-27 /pmc/articles/PMC8879966/ /pubmed/35207472 http://dx.doi.org/10.3390/life12020184 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Herreros-Pomares, Alejandro Identification, Culture and Targeting of Cancer Stem Cells |
title | Identification, Culture and Targeting of Cancer Stem Cells |
title_full | Identification, Culture and Targeting of Cancer Stem Cells |
title_fullStr | Identification, Culture and Targeting of Cancer Stem Cells |
title_full_unstemmed | Identification, Culture and Targeting of Cancer Stem Cells |
title_short | Identification, Culture and Targeting of Cancer Stem Cells |
title_sort | identification, culture and targeting of cancer stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879966/ https://www.ncbi.nlm.nih.gov/pubmed/35207472 http://dx.doi.org/10.3390/life12020184 |
work_keys_str_mv | AT herrerospomaresalejandro identificationcultureandtargetingofcancerstemcells |