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3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review
3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted for successful clinical implementation of these innovative drug products. Extensive research has been conducted on the compliance of 3D-print...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880000/ https://www.ncbi.nlm.nih.gov/pubmed/35214148 http://dx.doi.org/10.3390/pharmaceutics14020416 |
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author | Lafeber, Iris Ruijgrok, Elisabeth J. Guchelaar, Henk-Jan Schimmel, Kirsten J. M. |
author_facet | Lafeber, Iris Ruijgrok, Elisabeth J. Guchelaar, Henk-Jan Schimmel, Kirsten J. M. |
author_sort | Lafeber, Iris |
collection | PubMed |
description | 3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted for successful clinical implementation of these innovative drug products. Extensive research has been conducted on the compliance of 3D-printed drug products to a pediatric quality target product profile. The 3D-printed tablets were of particular interest in providing superior dosing and release profile similarity compared to conventional drug manipulation and compounding methods, such as oral liquids. In the future, acceptance of 3D-printed tablets in the pediatric patient population might be better than current treatments due to improved palatability. Further research should focus on expanding clinical knowledge, providing regulatory guidance and expansion of the product range, including dosage form possibilities. Moreover, it should enable the use of diverse good manufacturing practice (GMP)-ready 3D printing techniques for the production of various drug products for the pediatric patient population. |
format | Online Article Text |
id | pubmed-8880000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88800002022-02-26 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review Lafeber, Iris Ruijgrok, Elisabeth J. Guchelaar, Henk-Jan Schimmel, Kirsten J. M. Pharmaceutics Review 3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted for successful clinical implementation of these innovative drug products. Extensive research has been conducted on the compliance of 3D-printed drug products to a pediatric quality target product profile. The 3D-printed tablets were of particular interest in providing superior dosing and release profile similarity compared to conventional drug manipulation and compounding methods, such as oral liquids. In the future, acceptance of 3D-printed tablets in the pediatric patient population might be better than current treatments due to improved palatability. Further research should focus on expanding clinical knowledge, providing regulatory guidance and expansion of the product range, including dosage form possibilities. Moreover, it should enable the use of diverse good manufacturing practice (GMP)-ready 3D printing techniques for the production of various drug products for the pediatric patient population. MDPI 2022-02-14 /pmc/articles/PMC8880000/ /pubmed/35214148 http://dx.doi.org/10.3390/pharmaceutics14020416 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lafeber, Iris Ruijgrok, Elisabeth J. Guchelaar, Henk-Jan Schimmel, Kirsten J. M. 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review |
title | 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review |
title_full | 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review |
title_fullStr | 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review |
title_full_unstemmed | 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review |
title_short | 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review |
title_sort | 3d printing of pediatric medication: the end of bad tasting oral liquids?—a scoping review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880000/ https://www.ncbi.nlm.nih.gov/pubmed/35214148 http://dx.doi.org/10.3390/pharmaceutics14020416 |
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