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3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review

3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted for successful clinical implementation of these innovative drug products. Extensive research has been conducted on the compliance of 3D-print...

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Autores principales: Lafeber, Iris, Ruijgrok, Elisabeth J., Guchelaar, Henk-Jan, Schimmel, Kirsten J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880000/
https://www.ncbi.nlm.nih.gov/pubmed/35214148
http://dx.doi.org/10.3390/pharmaceutics14020416
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author Lafeber, Iris
Ruijgrok, Elisabeth J.
Guchelaar, Henk-Jan
Schimmel, Kirsten J. M.
author_facet Lafeber, Iris
Ruijgrok, Elisabeth J.
Guchelaar, Henk-Jan
Schimmel, Kirsten J. M.
author_sort Lafeber, Iris
collection PubMed
description 3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted for successful clinical implementation of these innovative drug products. Extensive research has been conducted on the compliance of 3D-printed drug products to a pediatric quality target product profile. The 3D-printed tablets were of particular interest in providing superior dosing and release profile similarity compared to conventional drug manipulation and compounding methods, such as oral liquids. In the future, acceptance of 3D-printed tablets in the pediatric patient population might be better than current treatments due to improved palatability. Further research should focus on expanding clinical knowledge, providing regulatory guidance and expansion of the product range, including dosage form possibilities. Moreover, it should enable the use of diverse good manufacturing practice (GMP)-ready 3D printing techniques for the production of various drug products for the pediatric patient population.
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spelling pubmed-88800002022-02-26 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review Lafeber, Iris Ruijgrok, Elisabeth J. Guchelaar, Henk-Jan Schimmel, Kirsten J. M. Pharmaceutics Review 3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted for successful clinical implementation of these innovative drug products. Extensive research has been conducted on the compliance of 3D-printed drug products to a pediatric quality target product profile. The 3D-printed tablets were of particular interest in providing superior dosing and release profile similarity compared to conventional drug manipulation and compounding methods, such as oral liquids. In the future, acceptance of 3D-printed tablets in the pediatric patient population might be better than current treatments due to improved palatability. Further research should focus on expanding clinical knowledge, providing regulatory guidance and expansion of the product range, including dosage form possibilities. Moreover, it should enable the use of diverse good manufacturing practice (GMP)-ready 3D printing techniques for the production of various drug products for the pediatric patient population. MDPI 2022-02-14 /pmc/articles/PMC8880000/ /pubmed/35214148 http://dx.doi.org/10.3390/pharmaceutics14020416 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lafeber, Iris
Ruijgrok, Elisabeth J.
Guchelaar, Henk-Jan
Schimmel, Kirsten J. M.
3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review
title 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review
title_full 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review
title_fullStr 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review
title_full_unstemmed 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review
title_short 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review
title_sort 3d printing of pediatric medication: the end of bad tasting oral liquids?—a scoping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880000/
https://www.ncbi.nlm.nih.gov/pubmed/35214148
http://dx.doi.org/10.3390/pharmaceutics14020416
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