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Hydroxypropyl-β-cyclodextrin Enhances Oral Absorption of Silymarin Nanoparticles Prepared Using PureNano™ Continuous Crystallizer

The oral bioavailability of drugs is limited by factors such as poor membrane permeability, low solubility, and low dissolution rate. Silymarin (SLM) is a health-food active ingredient that is good for immunosuppression and tumor suppression. However, obtaining a good oral bioavailability is difficu...

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Detalles Bibliográficos
Autores principales: Onodera, Risako, Hayashi, Tomohiro, Motoyama, Keiichi, Tahara, Kohei, Takeuchi, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880042/
https://www.ncbi.nlm.nih.gov/pubmed/35214124
http://dx.doi.org/10.3390/pharmaceutics14020394