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Multifunctional Membranes Based on β-Glucans and Chitosan Useful in Wound Treatment

In this work, bio-based membranes prepared using a crosslinked β-glucans–chitosan dispersed in the chitosan matrix useful in promoting wound healing were studied for the first-time. Wound healing is a process that includes sequential steps designed to restore the structure and function of damaged ce...

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Autores principales: Trombino, Sonia, Curcio, Federica, Di Gioia, Maria Luisa, Armentano, Biagio, Poerio, Teresa, Cassano, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880073/
https://www.ncbi.nlm.nih.gov/pubmed/35207043
http://dx.doi.org/10.3390/membranes12020121
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author Trombino, Sonia
Curcio, Federica
Di Gioia, Maria Luisa
Armentano, Biagio
Poerio, Teresa
Cassano, Roberta
author_facet Trombino, Sonia
Curcio, Federica
Di Gioia, Maria Luisa
Armentano, Biagio
Poerio, Teresa
Cassano, Roberta
author_sort Trombino, Sonia
collection PubMed
description In this work, bio-based membranes prepared using a crosslinked β-glucans–chitosan dispersed in the chitosan matrix useful in promoting wound healing were studied for the first-time. Wound healing is a process that includes sequential steps designed to restore the structure and function of damaged cells and tissue. To minimize damage and the risk of infection during the healing process and to promote restoration of the integrity of damaged tissue, the wound should be dressed. Generally, according to their function in the wound, dressings are classified on the basis of type of material and physical form. The substances used to make a dressing are generally natural polymers such as hydrocolloids, alginates, polyurethane, collagen, chitosan, pectin and hyaluronic acid. The combination of polymeric substances, with antibacterial and antioxidant properties, could be exploited in the biomedical field for the development of biocompatible materials able to act as a barrier between the wound and the external environment, protecting the site from bacterial contamination and promoting healing. To this aim, bio-based membranes were prepared by the phase inversion induced by solvent evaporation, using the crosslinked β-glucans–chitosan obtained by esterification reactions as a functional additive in the chitosan membrane. The reaction intermediates and the final products were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) while the morphological properties of membranes were analyzed using electronic scanning microscopy (SEM). The chemical bonding between chitosan and β-glucans allowed for the obtainment of a better dispersion of the combined new material into the membrane’s matrix and as a consequence, an enhanced antibacterial property evaluated through in vitro tests, with respect to the starting materials.
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spelling pubmed-88800732022-02-26 Multifunctional Membranes Based on β-Glucans and Chitosan Useful in Wound Treatment Trombino, Sonia Curcio, Federica Di Gioia, Maria Luisa Armentano, Biagio Poerio, Teresa Cassano, Roberta Membranes (Basel) Article In this work, bio-based membranes prepared using a crosslinked β-glucans–chitosan dispersed in the chitosan matrix useful in promoting wound healing were studied for the first-time. Wound healing is a process that includes sequential steps designed to restore the structure and function of damaged cells and tissue. To minimize damage and the risk of infection during the healing process and to promote restoration of the integrity of damaged tissue, the wound should be dressed. Generally, according to their function in the wound, dressings are classified on the basis of type of material and physical form. The substances used to make a dressing are generally natural polymers such as hydrocolloids, alginates, polyurethane, collagen, chitosan, pectin and hyaluronic acid. The combination of polymeric substances, with antibacterial and antioxidant properties, could be exploited in the biomedical field for the development of biocompatible materials able to act as a barrier between the wound and the external environment, protecting the site from bacterial contamination and promoting healing. To this aim, bio-based membranes were prepared by the phase inversion induced by solvent evaporation, using the crosslinked β-glucans–chitosan obtained by esterification reactions as a functional additive in the chitosan membrane. The reaction intermediates and the final products were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) while the morphological properties of membranes were analyzed using electronic scanning microscopy (SEM). The chemical bonding between chitosan and β-glucans allowed for the obtainment of a better dispersion of the combined new material into the membrane’s matrix and as a consequence, an enhanced antibacterial property evaluated through in vitro tests, with respect to the starting materials. MDPI 2022-01-20 /pmc/articles/PMC8880073/ /pubmed/35207043 http://dx.doi.org/10.3390/membranes12020121 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trombino, Sonia
Curcio, Federica
Di Gioia, Maria Luisa
Armentano, Biagio
Poerio, Teresa
Cassano, Roberta
Multifunctional Membranes Based on β-Glucans and Chitosan Useful in Wound Treatment
title Multifunctional Membranes Based on β-Glucans and Chitosan Useful in Wound Treatment
title_full Multifunctional Membranes Based on β-Glucans and Chitosan Useful in Wound Treatment
title_fullStr Multifunctional Membranes Based on β-Glucans and Chitosan Useful in Wound Treatment
title_full_unstemmed Multifunctional Membranes Based on β-Glucans and Chitosan Useful in Wound Treatment
title_short Multifunctional Membranes Based on β-Glucans and Chitosan Useful in Wound Treatment
title_sort multifunctional membranes based on β-glucans and chitosan useful in wound treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880073/
https://www.ncbi.nlm.nih.gov/pubmed/35207043
http://dx.doi.org/10.3390/membranes12020121
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