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Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study
Background: It is unclear whether the presence of minimal lung function impairment is an independent risk factor for the development of lung cancer in general populations. Methods: We conducted a population-based cohort study using nationally representative data from the Korean National Health and N...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880094/ https://www.ncbi.nlm.nih.gov/pubmed/35207361 http://dx.doi.org/10.3390/jcm11041077 |
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author | Kang, Hye Seon Park, Yong-Moon Ko, Seung-Hyun Kim, Seung Hoon Kim, Shin Young Kim, Chi Hong Han, Kyungdo Kim, Sung Kyoung |
author_facet | Kang, Hye Seon Park, Yong-Moon Ko, Seung-Hyun Kim, Seung Hoon Kim, Shin Young Kim, Chi Hong Han, Kyungdo Kim, Sung Kyoung |
author_sort | Kang, Hye Seon |
collection | PubMed |
description | Background: It is unclear whether the presence of minimal lung function impairment is an independent risk factor for the development of lung cancer in general populations. Methods: We conducted a population-based cohort study using nationally representative data from the Korean National Health and Nutrition Examination Survey and the Korean National Health Insurance Service. Results: Of 20,553 participants, 169 were diagnosed with lung cancer during follow-up (median, 6.5 years). Participants with obstructive lung function impairment had increased risk of lung cancer (aHR: 2.51; 95% CI: 1.729–3.629) compared with those with normal lung function. The lower was the quartile or decile of forced expiratory volume in one second (FEV1) or the FEV1/forced vital capacity (FVC) ratio, the significantly higher was the incidence rate of lung cancer (p for trend < 0.0001). With FEV1 values in the lowest quartile (Q4), the incidence of lung cancer was significantly increased regardless of FVC (FEV1 Q4 and FVC values in the higher three quartiles Q1–3: aHR 1.754; 95% CI 1.084–2.847, FEV1 Q4 and FVC Q4: aHR 1.889; 95% CI 1.331–2.681). Conclusion: Our findings suggest that minimal lung function impairment, as expressed by lower FEV1 or FEV1/FVC value, may be associated with increased risk of lung cancer |
format | Online Article Text |
id | pubmed-8880094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88800942022-02-26 Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study Kang, Hye Seon Park, Yong-Moon Ko, Seung-Hyun Kim, Seung Hoon Kim, Shin Young Kim, Chi Hong Han, Kyungdo Kim, Sung Kyoung J Clin Med Article Background: It is unclear whether the presence of minimal lung function impairment is an independent risk factor for the development of lung cancer in general populations. Methods: We conducted a population-based cohort study using nationally representative data from the Korean National Health and Nutrition Examination Survey and the Korean National Health Insurance Service. Results: Of 20,553 participants, 169 were diagnosed with lung cancer during follow-up (median, 6.5 years). Participants with obstructive lung function impairment had increased risk of lung cancer (aHR: 2.51; 95% CI: 1.729–3.629) compared with those with normal lung function. The lower was the quartile or decile of forced expiratory volume in one second (FEV1) or the FEV1/forced vital capacity (FVC) ratio, the significantly higher was the incidence rate of lung cancer (p for trend < 0.0001). With FEV1 values in the lowest quartile (Q4), the incidence of lung cancer was significantly increased regardless of FVC (FEV1 Q4 and FVC values in the higher three quartiles Q1–3: aHR 1.754; 95% CI 1.084–2.847, FEV1 Q4 and FVC Q4: aHR 1.889; 95% CI 1.331–2.681). Conclusion: Our findings suggest that minimal lung function impairment, as expressed by lower FEV1 or FEV1/FVC value, may be associated with increased risk of lung cancer MDPI 2022-02-18 /pmc/articles/PMC8880094/ /pubmed/35207361 http://dx.doi.org/10.3390/jcm11041077 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kang, Hye Seon Park, Yong-Moon Ko, Seung-Hyun Kim, Seung Hoon Kim, Shin Young Kim, Chi Hong Han, Kyungdo Kim, Sung Kyoung Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study |
title | Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study |
title_full | Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study |
title_fullStr | Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study |
title_full_unstemmed | Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study |
title_short | Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study |
title_sort | impaired lung function and lung cancer incidence: a nationwide population-based cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880094/ https://www.ncbi.nlm.nih.gov/pubmed/35207361 http://dx.doi.org/10.3390/jcm11041077 |
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