Cargando…

Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study

Background: It is unclear whether the presence of minimal lung function impairment is an independent risk factor for the development of lung cancer in general populations. Methods: We conducted a population-based cohort study using nationally representative data from the Korean National Health and N...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Hye Seon, Park, Yong-Moon, Ko, Seung-Hyun, Kim, Seung Hoon, Kim, Shin Young, Kim, Chi Hong, Han, Kyungdo, Kim, Sung Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880094/
https://www.ncbi.nlm.nih.gov/pubmed/35207361
http://dx.doi.org/10.3390/jcm11041077
_version_ 1784659093059796992
author Kang, Hye Seon
Park, Yong-Moon
Ko, Seung-Hyun
Kim, Seung Hoon
Kim, Shin Young
Kim, Chi Hong
Han, Kyungdo
Kim, Sung Kyoung
author_facet Kang, Hye Seon
Park, Yong-Moon
Ko, Seung-Hyun
Kim, Seung Hoon
Kim, Shin Young
Kim, Chi Hong
Han, Kyungdo
Kim, Sung Kyoung
author_sort Kang, Hye Seon
collection PubMed
description Background: It is unclear whether the presence of minimal lung function impairment is an independent risk factor for the development of lung cancer in general populations. Methods: We conducted a population-based cohort study using nationally representative data from the Korean National Health and Nutrition Examination Survey and the Korean National Health Insurance Service. Results: Of 20,553 participants, 169 were diagnosed with lung cancer during follow-up (median, 6.5 years). Participants with obstructive lung function impairment had increased risk of lung cancer (aHR: 2.51; 95% CI: 1.729–3.629) compared with those with normal lung function. The lower was the quartile or decile of forced expiratory volume in one second (FEV1) or the FEV1/forced vital capacity (FVC) ratio, the significantly higher was the incidence rate of lung cancer (p for trend < 0.0001). With FEV1 values in the lowest quartile (Q4), the incidence of lung cancer was significantly increased regardless of FVC (FEV1 Q4 and FVC values in the higher three quartiles Q1–3: aHR 1.754; 95% CI 1.084–2.847, FEV1 Q4 and FVC Q4: aHR 1.889; 95% CI 1.331–2.681). Conclusion: Our findings suggest that minimal lung function impairment, as expressed by lower FEV1 or FEV1/FVC value, may be associated with increased risk of lung cancer
format Online
Article
Text
id pubmed-8880094
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88800942022-02-26 Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study Kang, Hye Seon Park, Yong-Moon Ko, Seung-Hyun Kim, Seung Hoon Kim, Shin Young Kim, Chi Hong Han, Kyungdo Kim, Sung Kyoung J Clin Med Article Background: It is unclear whether the presence of minimal lung function impairment is an independent risk factor for the development of lung cancer in general populations. Methods: We conducted a population-based cohort study using nationally representative data from the Korean National Health and Nutrition Examination Survey and the Korean National Health Insurance Service. Results: Of 20,553 participants, 169 were diagnosed with lung cancer during follow-up (median, 6.5 years). Participants with obstructive lung function impairment had increased risk of lung cancer (aHR: 2.51; 95% CI: 1.729–3.629) compared with those with normal lung function. The lower was the quartile or decile of forced expiratory volume in one second (FEV1) or the FEV1/forced vital capacity (FVC) ratio, the significantly higher was the incidence rate of lung cancer (p for trend < 0.0001). With FEV1 values in the lowest quartile (Q4), the incidence of lung cancer was significantly increased regardless of FVC (FEV1 Q4 and FVC values in the higher three quartiles Q1–3: aHR 1.754; 95% CI 1.084–2.847, FEV1 Q4 and FVC Q4: aHR 1.889; 95% CI 1.331–2.681). Conclusion: Our findings suggest that minimal lung function impairment, as expressed by lower FEV1 or FEV1/FVC value, may be associated with increased risk of lung cancer MDPI 2022-02-18 /pmc/articles/PMC8880094/ /pubmed/35207361 http://dx.doi.org/10.3390/jcm11041077 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Hye Seon
Park, Yong-Moon
Ko, Seung-Hyun
Kim, Seung Hoon
Kim, Shin Young
Kim, Chi Hong
Han, Kyungdo
Kim, Sung Kyoung
Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study
title Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study
title_full Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study
title_fullStr Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study
title_full_unstemmed Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study
title_short Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study
title_sort impaired lung function and lung cancer incidence: a nationwide population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880094/
https://www.ncbi.nlm.nih.gov/pubmed/35207361
http://dx.doi.org/10.3390/jcm11041077
work_keys_str_mv AT kanghyeseon impairedlungfunctionandlungcancerincidenceanationwidepopulationbasedcohortstudy
AT parkyongmoon impairedlungfunctionandlungcancerincidenceanationwidepopulationbasedcohortstudy
AT koseunghyun impairedlungfunctionandlungcancerincidenceanationwidepopulationbasedcohortstudy
AT kimseunghoon impairedlungfunctionandlungcancerincidenceanationwidepopulationbasedcohortstudy
AT kimshinyoung impairedlungfunctionandlungcancerincidenceanationwidepopulationbasedcohortstudy
AT kimchihong impairedlungfunctionandlungcancerincidenceanationwidepopulationbasedcohortstudy
AT hankyungdo impairedlungfunctionandlungcancerincidenceanationwidepopulationbasedcohortstudy
AT kimsungkyoung impairedlungfunctionandlungcancerincidenceanationwidepopulationbasedcohortstudy