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Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data

Background and Objectives: The influence of smoking habits on mortality, VTE recurrence, and major bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Materials and Methods: We used data from the RIETE (Registro Enfermedad Trombo...

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Autores principales: Giorgi-Pierfranceschi, Matteo, Monreal, Manuel, Di Micco, Pierpaolo, Francisco, Iria, Hernández-Blasco, Luis, Madridano, Olga, López-Sáez, Juan Bosco, Hernando, Elena, Meireles, Jose, Dentali, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880138/
https://www.ncbi.nlm.nih.gov/pubmed/35208618
http://dx.doi.org/10.3390/medicina58020295
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author Giorgi-Pierfranceschi, Matteo
Monreal, Manuel
Di Micco, Pierpaolo
Francisco, Iria
Hernández-Blasco, Luis
Madridano, Olga
López-Sáez, Juan Bosco
Hernando, Elena
Meireles, Jose
Dentali, Francesco
author_facet Giorgi-Pierfranceschi, Matteo
Monreal, Manuel
Di Micco, Pierpaolo
Francisco, Iria
Hernández-Blasco, Luis
Madridano, Olga
López-Sáez, Juan Bosco
Hernando, Elena
Meireles, Jose
Dentali, Francesco
author_sort Giorgi-Pierfranceschi, Matteo
collection PubMed
description Background and Objectives: The influence of smoking habits on mortality, VTE recurrence, and major bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Materials and Methods: We used data from the RIETE (Registro Enfermedad TromboEmbólica) registry to compare mortality, VTE recurrence, and major bleeding risk in smoking versus non-smoking patients with acute VTE. Results: 50,881 patients (43,426 non-smoking and 7455 smoking patients) were included. After a median follow-up of 8.8 months, 7110 patients died (fatal PE 292 and fatal bleeding 281), 3243 presented VTE recurrence, and 1579 had major bleeding. At multivariate analysis, smoking behavior was associated with a higher hazard of death, (HR: 1.28; 95% CI: 1.19–1.40). The risk of VTE recurrence was marginally increased in smoking patients compared to non-smoking patients (1.14; 95% CI: 1.02–1.27). Major bleeding did not differ in smoking and non-smoking patients (1.15; 95% CI: 0.96–1.38). The presence of cancer did not appear to influence the association between smoking habits and death (HR: 1.34; 95% CI: 1.22–1.47 in cancer patients and HR: 1.23; 95% CI: 1.04, 1.45 in non-cancer patients, respectively) Conclusions: the risk of death after an acute episode of VTE appeared to be higher in smoking than in non-smoking patients and this risk is higher between patients presenting PE at the onset of symptoms.
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spelling pubmed-88801382022-02-26 Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data Giorgi-Pierfranceschi, Matteo Monreal, Manuel Di Micco, Pierpaolo Francisco, Iria Hernández-Blasco, Luis Madridano, Olga López-Sáez, Juan Bosco Hernando, Elena Meireles, Jose Dentali, Francesco Medicina (Kaunas) Article Background and Objectives: The influence of smoking habits on mortality, VTE recurrence, and major bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Materials and Methods: We used data from the RIETE (Registro Enfermedad TromboEmbólica) registry to compare mortality, VTE recurrence, and major bleeding risk in smoking versus non-smoking patients with acute VTE. Results: 50,881 patients (43,426 non-smoking and 7455 smoking patients) were included. After a median follow-up of 8.8 months, 7110 patients died (fatal PE 292 and fatal bleeding 281), 3243 presented VTE recurrence, and 1579 had major bleeding. At multivariate analysis, smoking behavior was associated with a higher hazard of death, (HR: 1.28; 95% CI: 1.19–1.40). The risk of VTE recurrence was marginally increased in smoking patients compared to non-smoking patients (1.14; 95% CI: 1.02–1.27). Major bleeding did not differ in smoking and non-smoking patients (1.15; 95% CI: 0.96–1.38). The presence of cancer did not appear to influence the association between smoking habits and death (HR: 1.34; 95% CI: 1.22–1.47 in cancer patients and HR: 1.23; 95% CI: 1.04, 1.45 in non-cancer patients, respectively) Conclusions: the risk of death after an acute episode of VTE appeared to be higher in smoking than in non-smoking patients and this risk is higher between patients presenting PE at the onset of symptoms. MDPI 2022-02-15 /pmc/articles/PMC8880138/ /pubmed/35208618 http://dx.doi.org/10.3390/medicina58020295 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Giorgi-Pierfranceschi, Matteo
Monreal, Manuel
Di Micco, Pierpaolo
Francisco, Iria
Hernández-Blasco, Luis
Madridano, Olga
López-Sáez, Juan Bosco
Hernando, Elena
Meireles, Jose
Dentali, Francesco
Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data
title Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data
title_full Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data
title_fullStr Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data
title_full_unstemmed Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data
title_short Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data
title_sort prognostic impact of active cigarette smoking on mortality in patients with acute venous thromboembolic events, findings from real world data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880138/
https://www.ncbi.nlm.nih.gov/pubmed/35208618
http://dx.doi.org/10.3390/medicina58020295
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