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Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol

The influenza virus has been known as a representative infectious virus that harms human health from the past to the present day. We have promoted the development of a novel adsorbent capable of adsorbing influenza viruses in the form of aerosols in the air. In this study, to develop a material to a...

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Autores principales: Kim, Yung-Yoon, Sagara, Kanta, Uezu, Kazuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880166/
https://www.ncbi.nlm.nih.gov/pubmed/35215575
http://dx.doi.org/10.3390/polym14040663
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author Kim, Yung-Yoon
Sagara, Kanta
Uezu, Kazuya
author_facet Kim, Yung-Yoon
Sagara, Kanta
Uezu, Kazuya
author_sort Kim, Yung-Yoon
collection PubMed
description The influenza virus has been known as a representative infectious virus that harms human health from the past to the present day. We have promoted the development of a novel adsorbent capable of adsorbing influenza viruses in the form of aerosols in the air. In this study, to develop a material to adsorb the influenza virus, a functional group was introduced into a microfiber nonwoven fabric (MNWF) manufactured through radiation-induced graft polymerization (RIGP), and sialic acid was immobilized to mimic the sugar chain cluster effect. The functional group was used by coupling disodium iminodiacetate monohydrate (IDA) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), and N-acetylneuraminic acid (NANA) was selected for sialic acid. IDA-EDC was introduced into GMA MNWF with an average molar conversion of 47%. For NANA MNWF with a degree of grafting (dg) of 87% introduced with sialic acid, 118.2 of 200 µg of aerosolized lectin was adsorbed, confirming that the maximum adsorption amount was 59.1%. In NANA MNWF of 100% or more dg, a tendency to decrease the amount of lectin adsorption was observed compared to NANA MNWF of 80–100% dg.
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spelling pubmed-88801662022-02-26 Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol Kim, Yung-Yoon Sagara, Kanta Uezu, Kazuya Polymers (Basel) Article The influenza virus has been known as a representative infectious virus that harms human health from the past to the present day. We have promoted the development of a novel adsorbent capable of adsorbing influenza viruses in the form of aerosols in the air. In this study, to develop a material to adsorb the influenza virus, a functional group was introduced into a microfiber nonwoven fabric (MNWF) manufactured through radiation-induced graft polymerization (RIGP), and sialic acid was immobilized to mimic the sugar chain cluster effect. The functional group was used by coupling disodium iminodiacetate monohydrate (IDA) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), and N-acetylneuraminic acid (NANA) was selected for sialic acid. IDA-EDC was introduced into GMA MNWF with an average molar conversion of 47%. For NANA MNWF with a degree of grafting (dg) of 87% introduced with sialic acid, 118.2 of 200 µg of aerosolized lectin was adsorbed, confirming that the maximum adsorption amount was 59.1%. In NANA MNWF of 100% or more dg, a tendency to decrease the amount of lectin adsorption was observed compared to NANA MNWF of 80–100% dg. MDPI 2022-02-09 /pmc/articles/PMC8880166/ /pubmed/35215575 http://dx.doi.org/10.3390/polym14040663 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Yung-Yoon
Sagara, Kanta
Uezu, Kazuya
Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol
title Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol
title_full Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol
title_fullStr Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol
title_full_unstemmed Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol
title_short Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol
title_sort functional microfiber nonwoven fabric with sialic acid-immobilized polymer brush for capturing lectin in aerosol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880166/
https://www.ncbi.nlm.nih.gov/pubmed/35215575
http://dx.doi.org/10.3390/polym14040663
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