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Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol
The influenza virus has been known as a representative infectious virus that harms human health from the past to the present day. We have promoted the development of a novel adsorbent capable of adsorbing influenza viruses in the form of aerosols in the air. In this study, to develop a material to a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880166/ https://www.ncbi.nlm.nih.gov/pubmed/35215575 http://dx.doi.org/10.3390/polym14040663 |
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author | Kim, Yung-Yoon Sagara, Kanta Uezu, Kazuya |
author_facet | Kim, Yung-Yoon Sagara, Kanta Uezu, Kazuya |
author_sort | Kim, Yung-Yoon |
collection | PubMed |
description | The influenza virus has been known as a representative infectious virus that harms human health from the past to the present day. We have promoted the development of a novel adsorbent capable of adsorbing influenza viruses in the form of aerosols in the air. In this study, to develop a material to adsorb the influenza virus, a functional group was introduced into a microfiber nonwoven fabric (MNWF) manufactured through radiation-induced graft polymerization (RIGP), and sialic acid was immobilized to mimic the sugar chain cluster effect. The functional group was used by coupling disodium iminodiacetate monohydrate (IDA) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), and N-acetylneuraminic acid (NANA) was selected for sialic acid. IDA-EDC was introduced into GMA MNWF with an average molar conversion of 47%. For NANA MNWF with a degree of grafting (dg) of 87% introduced with sialic acid, 118.2 of 200 µg of aerosolized lectin was adsorbed, confirming that the maximum adsorption amount was 59.1%. In NANA MNWF of 100% or more dg, a tendency to decrease the amount of lectin adsorption was observed compared to NANA MNWF of 80–100% dg. |
format | Online Article Text |
id | pubmed-8880166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88801662022-02-26 Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol Kim, Yung-Yoon Sagara, Kanta Uezu, Kazuya Polymers (Basel) Article The influenza virus has been known as a representative infectious virus that harms human health from the past to the present day. We have promoted the development of a novel adsorbent capable of adsorbing influenza viruses in the form of aerosols in the air. In this study, to develop a material to adsorb the influenza virus, a functional group was introduced into a microfiber nonwoven fabric (MNWF) manufactured through radiation-induced graft polymerization (RIGP), and sialic acid was immobilized to mimic the sugar chain cluster effect. The functional group was used by coupling disodium iminodiacetate monohydrate (IDA) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), and N-acetylneuraminic acid (NANA) was selected for sialic acid. IDA-EDC was introduced into GMA MNWF with an average molar conversion of 47%. For NANA MNWF with a degree of grafting (dg) of 87% introduced with sialic acid, 118.2 of 200 µg of aerosolized lectin was adsorbed, confirming that the maximum adsorption amount was 59.1%. In NANA MNWF of 100% or more dg, a tendency to decrease the amount of lectin adsorption was observed compared to NANA MNWF of 80–100% dg. MDPI 2022-02-09 /pmc/articles/PMC8880166/ /pubmed/35215575 http://dx.doi.org/10.3390/polym14040663 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Yung-Yoon Sagara, Kanta Uezu, Kazuya Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol |
title | Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol |
title_full | Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol |
title_fullStr | Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol |
title_full_unstemmed | Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol |
title_short | Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol |
title_sort | functional microfiber nonwoven fabric with sialic acid-immobilized polymer brush for capturing lectin in aerosol |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880166/ https://www.ncbi.nlm.nih.gov/pubmed/35215575 http://dx.doi.org/10.3390/polym14040663 |
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