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Free-Energy Profile Analysis of the Catalytic Reaction of Glycinamide Ribonucleotide Synthetase

The second step in the de novo biosynthetic pathway of purine is catalyzed by PurD, which consumes an ATP molecule to produce glycinamide ribonucleotide (GAR) from glycine and phosphoribosylamine (PRA). PurD initially reacts with ATP to produce an intermediate, glycyl-phosphate, which then reacts wi...

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Detalles Bibliográficos
Autores principales:	Yamamoto, Norifumi, Sampei, Genichi, Kawai, Gota
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880213/ https://www.ncbi.nlm.nih.gov/pubmed/35207568 http://dx.doi.org/10.3390/life12020281

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