Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms

Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimorphic fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic mycoses, the extent of disease and outcomes are the results of complex interactions between this opportunistic human patho...

Descripción completa

Detalles Bibliográficos
Autores principales: Pruksaphon, Kritsada, Nosanchuk, Joshua D., Ratanabanangkoon, Kavi, Youngchim, Sirida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880324/
https://www.ncbi.nlm.nih.gov/pubmed/35205954
http://dx.doi.org/10.3390/jof8020200
_version_ 1784659166268227584
author Pruksaphon, Kritsada
Nosanchuk, Joshua D.
Ratanabanangkoon, Kavi
Youngchim, Sirida
author_facet Pruksaphon, Kritsada
Nosanchuk, Joshua D.
Ratanabanangkoon, Kavi
Youngchim, Sirida
author_sort Pruksaphon, Kritsada
collection PubMed
description Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimorphic fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic mycoses, the extent of disease and outcomes are the results of complex interactions between this opportunistic human pathogen and a host’s immune response. This review will highlight the current knowledge regarding the dynamic interaction between T. marneffei and mammalian hosts, particularly highlighting important aspects of virulence factors, intracellular lifestyle and the mechanisms of immune defense as well as the strategies of the pathogen for manipulating and evading host immune cells.
format Online
Article
Text
id pubmed-8880324
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88803242022-02-26 Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms Pruksaphon, Kritsada Nosanchuk, Joshua D. Ratanabanangkoon, Kavi Youngchim, Sirida J Fungi (Basel) Review Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimorphic fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic mycoses, the extent of disease and outcomes are the results of complex interactions between this opportunistic human pathogen and a host’s immune response. This review will highlight the current knowledge regarding the dynamic interaction between T. marneffei and mammalian hosts, particularly highlighting important aspects of virulence factors, intracellular lifestyle and the mechanisms of immune defense as well as the strategies of the pathogen for manipulating and evading host immune cells. MDPI 2022-02-19 /pmc/articles/PMC8880324/ /pubmed/35205954 http://dx.doi.org/10.3390/jof8020200 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pruksaphon, Kritsada
Nosanchuk, Joshua D.
Ratanabanangkoon, Kavi
Youngchim, Sirida
Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms
title Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms
title_full Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms
title_fullStr Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms
title_full_unstemmed Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms
title_short Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms
title_sort talaromyces marneffei infection: virulence, intracellular lifestyle and host defense mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880324/
https://www.ncbi.nlm.nih.gov/pubmed/35205954
http://dx.doi.org/10.3390/jof8020200
work_keys_str_mv AT pruksaphonkritsada talaromycesmarneffeiinfectionvirulenceintracellularlifestyleandhostdefensemechanisms
AT nosanchukjoshuad talaromycesmarneffeiinfectionvirulenceintracellularlifestyleandhostdefensemechanisms
AT ratanabanangkoonkavi talaromycesmarneffeiinfectionvirulenceintracellularlifestyleandhostdefensemechanisms
AT youngchimsirida talaromycesmarneffeiinfectionvirulenceintracellularlifestyleandhostdefensemechanisms

Ejemplares similares