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Antigen-Presenting Cells in Psoriasis

Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in...

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Autores principales: Antal, Dóra, Alimohammadi, Shahrzad, Bai, Péter, Szöllősi, Attila Gábor, Szántó, Magdolna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880330/
https://www.ncbi.nlm.nih.gov/pubmed/35207521
http://dx.doi.org/10.3390/life12020234
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author Antal, Dóra
Alimohammadi, Shahrzad
Bai, Péter
Szöllősi, Attila Gábor
Szántó, Magdolna
author_facet Antal, Dóra
Alimohammadi, Shahrzad
Bai, Péter
Szöllősi, Attila Gábor
Szántó, Magdolna
author_sort Antal, Dóra
collection PubMed
description Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in the skin include dendritic cells, Langerhans cells and monocytes/macrophages. In addition, epidermal keratinocytes and dermal mast cells are also endowed with antigen-presenting capacity. Skin APCs have central role in the maintenance of cutaneous immune homeostasis, as well as in initiating and sustaining inflammation under pathologic conditions. In this review we discuss the functional specialization of human skin APCs that promote T cell activation and adaptive immune response during psoriasis initiation and onset.
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spelling pubmed-88803302022-02-26 Antigen-Presenting Cells in Psoriasis Antal, Dóra Alimohammadi, Shahrzad Bai, Péter Szöllősi, Attila Gábor Szántó, Magdolna Life (Basel) Communication Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in the skin include dendritic cells, Langerhans cells and monocytes/macrophages. In addition, epidermal keratinocytes and dermal mast cells are also endowed with antigen-presenting capacity. Skin APCs have central role in the maintenance of cutaneous immune homeostasis, as well as in initiating and sustaining inflammation under pathologic conditions. In this review we discuss the functional specialization of human skin APCs that promote T cell activation and adaptive immune response during psoriasis initiation and onset. MDPI 2022-02-03 /pmc/articles/PMC8880330/ /pubmed/35207521 http://dx.doi.org/10.3390/life12020234 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Antal, Dóra
Alimohammadi, Shahrzad
Bai, Péter
Szöllősi, Attila Gábor
Szántó, Magdolna
Antigen-Presenting Cells in Psoriasis
title Antigen-Presenting Cells in Psoriasis
title_full Antigen-Presenting Cells in Psoriasis
title_fullStr Antigen-Presenting Cells in Psoriasis
title_full_unstemmed Antigen-Presenting Cells in Psoriasis
title_short Antigen-Presenting Cells in Psoriasis
title_sort antigen-presenting cells in psoriasis
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880330/
https://www.ncbi.nlm.nih.gov/pubmed/35207521
http://dx.doi.org/10.3390/life12020234
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AT szantomagdolna antigenpresentingcellsinpsoriasis