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Antigen-Presenting Cells in Psoriasis
Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880330/ https://www.ncbi.nlm.nih.gov/pubmed/35207521 http://dx.doi.org/10.3390/life12020234 |
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author | Antal, Dóra Alimohammadi, Shahrzad Bai, Péter Szöllősi, Attila Gábor Szántó, Magdolna |
author_facet | Antal, Dóra Alimohammadi, Shahrzad Bai, Péter Szöllősi, Attila Gábor Szántó, Magdolna |
author_sort | Antal, Dóra |
collection | PubMed |
description | Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in the skin include dendritic cells, Langerhans cells and monocytes/macrophages. In addition, epidermal keratinocytes and dermal mast cells are also endowed with antigen-presenting capacity. Skin APCs have central role in the maintenance of cutaneous immune homeostasis, as well as in initiating and sustaining inflammation under pathologic conditions. In this review we discuss the functional specialization of human skin APCs that promote T cell activation and adaptive immune response during psoriasis initiation and onset. |
format | Online Article Text |
id | pubmed-8880330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88803302022-02-26 Antigen-Presenting Cells in Psoriasis Antal, Dóra Alimohammadi, Shahrzad Bai, Péter Szöllősi, Attila Gábor Szántó, Magdolna Life (Basel) Communication Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in the skin include dendritic cells, Langerhans cells and monocytes/macrophages. In addition, epidermal keratinocytes and dermal mast cells are also endowed with antigen-presenting capacity. Skin APCs have central role in the maintenance of cutaneous immune homeostasis, as well as in initiating and sustaining inflammation under pathologic conditions. In this review we discuss the functional specialization of human skin APCs that promote T cell activation and adaptive immune response during psoriasis initiation and onset. MDPI 2022-02-03 /pmc/articles/PMC8880330/ /pubmed/35207521 http://dx.doi.org/10.3390/life12020234 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Antal, Dóra Alimohammadi, Shahrzad Bai, Péter Szöllősi, Attila Gábor Szántó, Magdolna Antigen-Presenting Cells in Psoriasis |
title | Antigen-Presenting Cells in Psoriasis |
title_full | Antigen-Presenting Cells in Psoriasis |
title_fullStr | Antigen-Presenting Cells in Psoriasis |
title_full_unstemmed | Antigen-Presenting Cells in Psoriasis |
title_short | Antigen-Presenting Cells in Psoriasis |
title_sort | antigen-presenting cells in psoriasis |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880330/ https://www.ncbi.nlm.nih.gov/pubmed/35207521 http://dx.doi.org/10.3390/life12020234 |
work_keys_str_mv | AT antaldora antigenpresentingcellsinpsoriasis AT alimohammadishahrzad antigenpresentingcellsinpsoriasis AT baipeter antigenpresentingcellsinpsoriasis AT szollosiattilagabor antigenpresentingcellsinpsoriasis AT szantomagdolna antigenpresentingcellsinpsoriasis |