Cargando…
Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment
Advances in the early diagnosis and treatment have led to increases in breast cancer survivorship. Survivors report cognitive impairment symptoms such as loss of concentration and learning and memory deficits which significantly reduce the patient’s quality of life. Additional therapies are needed t...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880369/ https://www.ncbi.nlm.nih.gov/pubmed/35216124 http://dx.doi.org/10.3390/ijms23042008 |
_version_ | 1784659179073437696 |
---|---|
author | Ntagwabira, Fabio Trujillo, Madison McElroy, Taylor Brown, Taurean Simmons, Pilar Sykes, Delawerence Allen, Antiño R. |
author_facet | Ntagwabira, Fabio Trujillo, Madison McElroy, Taylor Brown, Taurean Simmons, Pilar Sykes, Delawerence Allen, Antiño R. |
author_sort | Ntagwabira, Fabio |
collection | PubMed |
description | Advances in the early diagnosis and treatment have led to increases in breast cancer survivorship. Survivors report cognitive impairment symptoms such as loss of concentration and learning and memory deficits which significantly reduce the patient’s quality of life. Additional therapies are needed to prevent these side effects and, the precise mechanisms of action responsible are not fully elucidated. However, increasing evidence points toward the use of neuroprotective compounds with antioxidants and anti-inflammatory properties as tools for conserving learning and memory. Here, we examine the ability of piperlongumine (PL), an alkaloid known to have anti-inflammatory and antioxidant effects, to play a neuroprotective role in 16-week-old female C57BL/6J mice treated with a common breast cancer regimen of doxorubicin, cyclophosphamide, and docetaxel (TAC). During social memory testing, TAC-treated mice exhibited impairment, while TAC/PL co-treated mice did not exhibit measurable social memory deficits. Proteomics analysis showed ERK1/2 signaling is involved in TAC and TAC/PL co-treatment. Reduced Nrf2 mRNA expression was also observed. mRNA levels of Gria2 were increased in TAC treated mice and reduced in TAC/PL co-treated mice. In this study, PL protects against social memory impairment when co-administered with TAC via multifactorial mechanisms involving oxidative stress and synaptic plasticity. |
format | Online Article Text |
id | pubmed-8880369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88803692022-02-26 Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment Ntagwabira, Fabio Trujillo, Madison McElroy, Taylor Brown, Taurean Simmons, Pilar Sykes, Delawerence Allen, Antiño R. Int J Mol Sci Article Advances in the early diagnosis and treatment have led to increases in breast cancer survivorship. Survivors report cognitive impairment symptoms such as loss of concentration and learning and memory deficits which significantly reduce the patient’s quality of life. Additional therapies are needed to prevent these side effects and, the precise mechanisms of action responsible are not fully elucidated. However, increasing evidence points toward the use of neuroprotective compounds with antioxidants and anti-inflammatory properties as tools for conserving learning and memory. Here, we examine the ability of piperlongumine (PL), an alkaloid known to have anti-inflammatory and antioxidant effects, to play a neuroprotective role in 16-week-old female C57BL/6J mice treated with a common breast cancer regimen of doxorubicin, cyclophosphamide, and docetaxel (TAC). During social memory testing, TAC-treated mice exhibited impairment, while TAC/PL co-treated mice did not exhibit measurable social memory deficits. Proteomics analysis showed ERK1/2 signaling is involved in TAC and TAC/PL co-treatment. Reduced Nrf2 mRNA expression was also observed. mRNA levels of Gria2 were increased in TAC treated mice and reduced in TAC/PL co-treated mice. In this study, PL protects against social memory impairment when co-administered with TAC via multifactorial mechanisms involving oxidative stress and synaptic plasticity. MDPI 2022-02-11 /pmc/articles/PMC8880369/ /pubmed/35216124 http://dx.doi.org/10.3390/ijms23042008 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ntagwabira, Fabio Trujillo, Madison McElroy, Taylor Brown, Taurean Simmons, Pilar Sykes, Delawerence Allen, Antiño R. Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment |
title | Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment |
title_full | Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment |
title_fullStr | Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment |
title_full_unstemmed | Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment |
title_short | Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment |
title_sort | piperlongumine as a neuro-protectant in chemotherapy induced cognitive impairment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880369/ https://www.ncbi.nlm.nih.gov/pubmed/35216124 http://dx.doi.org/10.3390/ijms23042008 |
work_keys_str_mv | AT ntagwabirafabio piperlongumineasaneuroprotectantinchemotherapyinducedcognitiveimpairment AT trujillomadison piperlongumineasaneuroprotectantinchemotherapyinducedcognitiveimpairment AT mcelroytaylor piperlongumineasaneuroprotectantinchemotherapyinducedcognitiveimpairment AT browntaurean piperlongumineasaneuroprotectantinchemotherapyinducedcognitiveimpairment AT simmonspilar piperlongumineasaneuroprotectantinchemotherapyinducedcognitiveimpairment AT sykesdelawerence piperlongumineasaneuroprotectantinchemotherapyinducedcognitiveimpairment AT allenantinor piperlongumineasaneuroprotectantinchemotherapyinducedcognitiveimpairment |