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Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet

Background and Objectives: The currently used pharmacological agents for metabolic disorders such as type II diabetes have several limitations and adverse effects; thus, there is a need for alternative therapeutic drugs and health functional foods. Materials and Methods: This study investigated the...

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Autores principales: Kang, Hyun-Gu, Bashir, Khawaja Muhammad Imran, Kim, Ki-Young, Shin, Su, Choi, Min-Woo, Hong, Eun-Jin, Choi, Seong-Hun, Kim, Joo-Wan, Choi, Jae-Suk, Ku, Sae-Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880371/
https://www.ncbi.nlm.nih.gov/pubmed/35208513
http://dx.doi.org/10.3390/medicina58020189
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author Kang, Hyun-Gu
Bashir, Khawaja Muhammad Imran
Kim, Ki-Young
Shin, Su
Choi, Min-Woo
Hong, Eun-Jin
Choi, Seong-Hun
Kim, Joo-Wan
Choi, Jae-Suk
Ku, Sae-Kwang
author_facet Kang, Hyun-Gu
Bashir, Khawaja Muhammad Imran
Kim, Ki-Young
Shin, Su
Choi, Min-Woo
Hong, Eun-Jin
Choi, Seong-Hun
Kim, Joo-Wan
Choi, Jae-Suk
Ku, Sae-Kwang
author_sort Kang, Hyun-Gu
collection PubMed
description Background and Objectives: The currently used pharmacological agents for metabolic disorders such as type II diabetes have several limitations and adverse effects; thus, there is a need for alternative therapeutic drugs and health functional foods. Materials and Methods: This study investigated the pharmacological effects of water chestnut (fruit of Trapa japonica) extracts (WC: 50–200 mg/kg) for type II diabetes using a 45% Kcal high-fat diet (HFD)-fed type II obese diabetic mice model for a period of 84 days, and the effects were compared to those of metformin (250 mg/kg). Results: Increases in body weight, serum biochemical indices such as triglycerides, low-density lipoprotein, and blood urea nitrogen, increases in antioxidant defense system enzymes such as catalase, superoxide dismutase, and glutathione, and mRNA expressions (such as AMPKα1 and AMPKα2) in the liver tissue and mRNA expressions (such as AMPKα2 mRNA, leptin, and C/EBPα) in the adipose tissue were observed in the HFD control group. The WC (50 mg/kg)-administered group showed no significant improvements in diabetic complications. However, HFD-induced obesity and diabetes-related complications such as hyperlipidemia, diabetic nephropathy, nonalcoholic fatty liver disease (NAFLD), oxidative stress, activity of antioxidant defense systems, and gene expressions were significantly and dose-dependently inhibited and/or normalized by oral administration of WC (100 mg/kg and 200 mg/kg), particularly at a dose of 100 mg/kg. Conclusions: The results of this study suggest that WC at an appropriate dose could be used to develop an effective therapeutic drug or functional food for type II diabetes and various associated complications, including NAFLD.
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spelling pubmed-88803712022-02-26 Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet Kang, Hyun-Gu Bashir, Khawaja Muhammad Imran Kim, Ki-Young Shin, Su Choi, Min-Woo Hong, Eun-Jin Choi, Seong-Hun Kim, Joo-Wan Choi, Jae-Suk Ku, Sae-Kwang Medicina (Kaunas) Article Background and Objectives: The currently used pharmacological agents for metabolic disorders such as type II diabetes have several limitations and adverse effects; thus, there is a need for alternative therapeutic drugs and health functional foods. Materials and Methods: This study investigated the pharmacological effects of water chestnut (fruit of Trapa japonica) extracts (WC: 50–200 mg/kg) for type II diabetes using a 45% Kcal high-fat diet (HFD)-fed type II obese diabetic mice model for a period of 84 days, and the effects were compared to those of metformin (250 mg/kg). Results: Increases in body weight, serum biochemical indices such as triglycerides, low-density lipoprotein, and blood urea nitrogen, increases in antioxidant defense system enzymes such as catalase, superoxide dismutase, and glutathione, and mRNA expressions (such as AMPKα1 and AMPKα2) in the liver tissue and mRNA expressions (such as AMPKα2 mRNA, leptin, and C/EBPα) in the adipose tissue were observed in the HFD control group. The WC (50 mg/kg)-administered group showed no significant improvements in diabetic complications. However, HFD-induced obesity and diabetes-related complications such as hyperlipidemia, diabetic nephropathy, nonalcoholic fatty liver disease (NAFLD), oxidative stress, activity of antioxidant defense systems, and gene expressions were significantly and dose-dependently inhibited and/or normalized by oral administration of WC (100 mg/kg and 200 mg/kg), particularly at a dose of 100 mg/kg. Conclusions: The results of this study suggest that WC at an appropriate dose could be used to develop an effective therapeutic drug or functional food for type II diabetes and various associated complications, including NAFLD. MDPI 2022-01-26 /pmc/articles/PMC8880371/ /pubmed/35208513 http://dx.doi.org/10.3390/medicina58020189 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Hyun-Gu
Bashir, Khawaja Muhammad Imran
Kim, Ki-Young
Shin, Su
Choi, Min-Woo
Hong, Eun-Jin
Choi, Seong-Hun
Kim, Joo-Wan
Choi, Jae-Suk
Ku, Sae-Kwang
Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet
title Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet
title_full Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet
title_fullStr Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet
title_full_unstemmed Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet
title_short Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet
title_sort evaluation of dose-dependent obesity and diabetes-related complications of water chestnut (fruit of trapa japonica) extracts in type ii obese diabetic mice induced by 45% kcal high-fat diet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880371/
https://www.ncbi.nlm.nih.gov/pubmed/35208513
http://dx.doi.org/10.3390/medicina58020189
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