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Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research

Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has b...

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Detalles Bibliográficos
Autores principales: Peterson, Nelson T., Vezina, Chad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880407/
https://www.ncbi.nlm.nih.gov/pubmed/35202275
http://dx.doi.org/10.3390/toxics10020089
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author Peterson, Nelson T.
Vezina, Chad M.
author_facet Peterson, Nelson T.
Vezina, Chad M.
author_sort Peterson, Nelson T.
collection PubMed
description Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has been dedicated to the influence of environmental chemicals on disease initiation, progression, or severity. Despite a few recent studies indicating a potential developmental origin of male LUTD linked to chemical exposures in the womb, it remains a grossly understudied endpoint in toxicology research. Therefore, we direct this review to toxicologists who are considering male LUTD as a new aspect of chemical toxicity studies. We focus on the LUTD disease process in men, as well as in the male mouse as a leading research model. To introduce the disease process, we describe the physiology of the male lower urinary tract and the cellular composition of lower urinary tract tissues. We discuss known and suspected mechanisms of male LUTD and examples of environmental chemicals acting through these mechanisms to contribute to LUTD. We also describe mouse models of LUTD and endpoints to diagnose, characterize, and quantify LUTD in men and mice.
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spelling pubmed-88804072022-02-26 Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research Peterson, Nelson T. Vezina, Chad M. Toxics Review Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has been dedicated to the influence of environmental chemicals on disease initiation, progression, or severity. Despite a few recent studies indicating a potential developmental origin of male LUTD linked to chemical exposures in the womb, it remains a grossly understudied endpoint in toxicology research. Therefore, we direct this review to toxicologists who are considering male LUTD as a new aspect of chemical toxicity studies. We focus on the LUTD disease process in men, as well as in the male mouse as a leading research model. To introduce the disease process, we describe the physiology of the male lower urinary tract and the cellular composition of lower urinary tract tissues. We discuss known and suspected mechanisms of male LUTD and examples of environmental chemicals acting through these mechanisms to contribute to LUTD. We also describe mouse models of LUTD and endpoints to diagnose, characterize, and quantify LUTD in men and mice. MDPI 2022-02-16 /pmc/articles/PMC8880407/ /pubmed/35202275 http://dx.doi.org/10.3390/toxics10020089 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Peterson, Nelson T.
Vezina, Chad M.
Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research
title Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research
title_full Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research
title_fullStr Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research
title_full_unstemmed Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research
title_short Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research
title_sort male lower urinary tract dysfunction: an underrepresented endpoint in toxicology research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880407/
https://www.ncbi.nlm.nih.gov/pubmed/35202275
http://dx.doi.org/10.3390/toxics10020089
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