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Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization
The goal of our study was to evaluate the burden of endometriosis in the community by comparing healthcare resource utilization, total direct medical costs, infertility, and comorbidity rates of women with and without a diagnosis of endometriosis. A retrospective case–control study was performed usi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880408/ https://www.ncbi.nlm.nih.gov/pubmed/35207404 http://dx.doi.org/10.3390/jcm11041133 |
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author | Eisenberg, Vered H. Decter, Dean H. Chodick, Gabriel Shalev, Varda Weil, Clara |
author_facet | Eisenberg, Vered H. Decter, Dean H. Chodick, Gabriel Shalev, Varda Weil, Clara |
author_sort | Eisenberg, Vered H. |
collection | PubMed |
description | The goal of our study was to evaluate the burden of endometriosis in the community by comparing healthcare resource utilization, total direct medical costs, infertility, and comorbidity rates of women with and without a diagnosis of endometriosis. A retrospective case–control study was performed using the databases of a 2.1 million-member nationwide healthcare plan. The study population included women aged 15–55 years enrolled in the healthcare plan. Women with a diagnosis (ICD-9) of endometriosis were compared to controls without diagnosed endometriosis. Women were individually matched (1:4) on age and residence area. Patient characteristics were described, including infertility, comorbidities, and annual healthcare resource utilization. Total direct medical costs were analyzed in a generalized linear model adjusting for age. Women with endometriosis (n = 6146, mean age ± SD: 40.4 ± 8.0 y) were significantly more likely than controls (n = 24,572) to have a lower BMI and a higher socioeconomic status. After adjusting for BMI and socioeconomic status, endometriosis was significantly associated with infertility (OR = 3.3; 95% CI 3.1–3.5), chronic comorbidities, higher utilization of healthcare services (hospitalization: OR = 2.3; 95% CI 2.1–2.5), pain medications, and antidepressants. Women aged 15–19 y with endometriosis had substantially higher utilization of primary care visits (57.7% vs. 14.4%) and oral contraceptive use (76.9% vs. 9.6%). Direct medical costs associated with endometriosis were higher than those for controls (OR = 1.75; 95% CI 1.69–1.85). Endometriosis is associated with a high burden of comorbidities, increased healthcare resource utilization, and excess costs, particularly for younger patients whose healthcare needs may differ widely from the older population. |
format | Online Article Text |
id | pubmed-8880408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88804082022-02-26 Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization Eisenberg, Vered H. Decter, Dean H. Chodick, Gabriel Shalev, Varda Weil, Clara J Clin Med Article The goal of our study was to evaluate the burden of endometriosis in the community by comparing healthcare resource utilization, total direct medical costs, infertility, and comorbidity rates of women with and without a diagnosis of endometriosis. A retrospective case–control study was performed using the databases of a 2.1 million-member nationwide healthcare plan. The study population included women aged 15–55 years enrolled in the healthcare plan. Women with a diagnosis (ICD-9) of endometriosis were compared to controls without diagnosed endometriosis. Women were individually matched (1:4) on age and residence area. Patient characteristics were described, including infertility, comorbidities, and annual healthcare resource utilization. Total direct medical costs were analyzed in a generalized linear model adjusting for age. Women with endometriosis (n = 6146, mean age ± SD: 40.4 ± 8.0 y) were significantly more likely than controls (n = 24,572) to have a lower BMI and a higher socioeconomic status. After adjusting for BMI and socioeconomic status, endometriosis was significantly associated with infertility (OR = 3.3; 95% CI 3.1–3.5), chronic comorbidities, higher utilization of healthcare services (hospitalization: OR = 2.3; 95% CI 2.1–2.5), pain medications, and antidepressants. Women aged 15–19 y with endometriosis had substantially higher utilization of primary care visits (57.7% vs. 14.4%) and oral contraceptive use (76.9% vs. 9.6%). Direct medical costs associated with endometriosis were higher than those for controls (OR = 1.75; 95% CI 1.69–1.85). Endometriosis is associated with a high burden of comorbidities, increased healthcare resource utilization, and excess costs, particularly for younger patients whose healthcare needs may differ widely from the older population. MDPI 2022-02-21 /pmc/articles/PMC8880408/ /pubmed/35207404 http://dx.doi.org/10.3390/jcm11041133 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Eisenberg, Vered H. Decter, Dean H. Chodick, Gabriel Shalev, Varda Weil, Clara Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization |
title | Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization |
title_full | Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization |
title_fullStr | Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization |
title_full_unstemmed | Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization |
title_short | Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization |
title_sort | burden of endometriosis: infertility, comorbidities, and healthcare resource utilization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880408/ https://www.ncbi.nlm.nih.gov/pubmed/35207404 http://dx.doi.org/10.3390/jcm11041133 |
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