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Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond
Non-enzymatic glycation is an unavoidable reaction that occurs across biological taxa. The final products of this irreversible reaction are called advanced glycation end-products (AGEs). The endogenously formed AGEs are known to be bioactive and detrimental to human health. Additionally, exogenous f...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880422/ https://www.ncbi.nlm.nih.gov/pubmed/35216202 http://dx.doi.org/10.3390/ijms23042086 |
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author | Oshima, Yu Harashima, Ai Munesue, Seiichi Kimura, Kumi Leerach, Nontaphat Goto, Hisanori Tanaka, Mariko Niimura, Akane Hayashi, Kenjiro Yamamoto, Hiroshi Higashida, Haruhiro Yamamoto, Yasuhiko |
author_facet | Oshima, Yu Harashima, Ai Munesue, Seiichi Kimura, Kumi Leerach, Nontaphat Goto, Hisanori Tanaka, Mariko Niimura, Akane Hayashi, Kenjiro Yamamoto, Hiroshi Higashida, Haruhiro Yamamoto, Yasuhiko |
author_sort | Oshima, Yu |
collection | PubMed |
description | Non-enzymatic glycation is an unavoidable reaction that occurs across biological taxa. The final products of this irreversible reaction are called advanced glycation end-products (AGEs). The endogenously formed AGEs are known to be bioactive and detrimental to human health. Additionally, exogenous food-derived AGEs are debated to contribute to the development of aging and various diseases. Receptor for AGEs (RAGE) is widely known to elicit biological reactions. The binding of RAGE to other ligands (e.g., high mobility group box 1, S100 proteins, lipopolysaccharides, and amyloid-β) can result in pathological processes via the activation of intracellular RAGE signaling pathways, including inflammation, diabetes, aging, cancer growth, and metastasis. RAGE is now recognized as a pattern-recognition receptor. All mammals have RAGE homologs; however, other vertebrates, such as birds, amphibians, fish, and reptiles, do not have RAGE at the genomic level. This evidence from an evolutionary perspective allows us to understand why mammals require RAGE. In this review, we provide an overview of the scientific knowledge about the role of RAGE in physiological and pathological processes. In particular, we focus on (1) RAGE biology, (2) the role of RAGE in physiological and pathophysiological processes, (3) RAGE isoforms, including full-length membrane-bound RAGE (mRAGE), and the soluble forms of RAGE (sRAGE), which comprise endogenous secretory RAGE (esRAGE) and an ectodomain-shed form of RAGE, and (4) oxytocin transporters in the brain and intestine, which are important for maternal bonding and social behaviors. |
format | Online Article Text |
id | pubmed-8880422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88804222022-02-26 Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond Oshima, Yu Harashima, Ai Munesue, Seiichi Kimura, Kumi Leerach, Nontaphat Goto, Hisanori Tanaka, Mariko Niimura, Akane Hayashi, Kenjiro Yamamoto, Hiroshi Higashida, Haruhiro Yamamoto, Yasuhiko Int J Mol Sci Review Non-enzymatic glycation is an unavoidable reaction that occurs across biological taxa. The final products of this irreversible reaction are called advanced glycation end-products (AGEs). The endogenously formed AGEs are known to be bioactive and detrimental to human health. Additionally, exogenous food-derived AGEs are debated to contribute to the development of aging and various diseases. Receptor for AGEs (RAGE) is widely known to elicit biological reactions. The binding of RAGE to other ligands (e.g., high mobility group box 1, S100 proteins, lipopolysaccharides, and amyloid-β) can result in pathological processes via the activation of intracellular RAGE signaling pathways, including inflammation, diabetes, aging, cancer growth, and metastasis. RAGE is now recognized as a pattern-recognition receptor. All mammals have RAGE homologs; however, other vertebrates, such as birds, amphibians, fish, and reptiles, do not have RAGE at the genomic level. This evidence from an evolutionary perspective allows us to understand why mammals require RAGE. In this review, we provide an overview of the scientific knowledge about the role of RAGE in physiological and pathological processes. In particular, we focus on (1) RAGE biology, (2) the role of RAGE in physiological and pathophysiological processes, (3) RAGE isoforms, including full-length membrane-bound RAGE (mRAGE), and the soluble forms of RAGE (sRAGE), which comprise endogenous secretory RAGE (esRAGE) and an ectodomain-shed form of RAGE, and (4) oxytocin transporters in the brain and intestine, which are important for maternal bonding and social behaviors. MDPI 2022-02-14 /pmc/articles/PMC8880422/ /pubmed/35216202 http://dx.doi.org/10.3390/ijms23042086 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Oshima, Yu Harashima, Ai Munesue, Seiichi Kimura, Kumi Leerach, Nontaphat Goto, Hisanori Tanaka, Mariko Niimura, Akane Hayashi, Kenjiro Yamamoto, Hiroshi Higashida, Haruhiro Yamamoto, Yasuhiko Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond |
title | Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond |
title_full | Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond |
title_fullStr | Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond |
title_full_unstemmed | Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond |
title_short | Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond |
title_sort | dual nature of rage in host reaction and nurturing the mother–infant bond |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880422/ https://www.ncbi.nlm.nih.gov/pubmed/35216202 http://dx.doi.org/10.3390/ijms23042086 |
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