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Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond

Non-enzymatic glycation is an unavoidable reaction that occurs across biological taxa. The final products of this irreversible reaction are called advanced glycation end-products (AGEs). The endogenously formed AGEs are known to be bioactive and detrimental to human health. Additionally, exogenous f...

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Autores principales: Oshima, Yu, Harashima, Ai, Munesue, Seiichi, Kimura, Kumi, Leerach, Nontaphat, Goto, Hisanori, Tanaka, Mariko, Niimura, Akane, Hayashi, Kenjiro, Yamamoto, Hiroshi, Higashida, Haruhiro, Yamamoto, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880422/
https://www.ncbi.nlm.nih.gov/pubmed/35216202
http://dx.doi.org/10.3390/ijms23042086
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author Oshima, Yu
Harashima, Ai
Munesue, Seiichi
Kimura, Kumi
Leerach, Nontaphat
Goto, Hisanori
Tanaka, Mariko
Niimura, Akane
Hayashi, Kenjiro
Yamamoto, Hiroshi
Higashida, Haruhiro
Yamamoto, Yasuhiko
author_facet Oshima, Yu
Harashima, Ai
Munesue, Seiichi
Kimura, Kumi
Leerach, Nontaphat
Goto, Hisanori
Tanaka, Mariko
Niimura, Akane
Hayashi, Kenjiro
Yamamoto, Hiroshi
Higashida, Haruhiro
Yamamoto, Yasuhiko
author_sort Oshima, Yu
collection PubMed
description Non-enzymatic glycation is an unavoidable reaction that occurs across biological taxa. The final products of this irreversible reaction are called advanced glycation end-products (AGEs). The endogenously formed AGEs are known to be bioactive and detrimental to human health. Additionally, exogenous food-derived AGEs are debated to contribute to the development of aging and various diseases. Receptor for AGEs (RAGE) is widely known to elicit biological reactions. The binding of RAGE to other ligands (e.g., high mobility group box 1, S100 proteins, lipopolysaccharides, and amyloid-β) can result in pathological processes via the activation of intracellular RAGE signaling pathways, including inflammation, diabetes, aging, cancer growth, and metastasis. RAGE is now recognized as a pattern-recognition receptor. All mammals have RAGE homologs; however, other vertebrates, such as birds, amphibians, fish, and reptiles, do not have RAGE at the genomic level. This evidence from an evolutionary perspective allows us to understand why mammals require RAGE. In this review, we provide an overview of the scientific knowledge about the role of RAGE in physiological and pathological processes. In particular, we focus on (1) RAGE biology, (2) the role of RAGE in physiological and pathophysiological processes, (3) RAGE isoforms, including full-length membrane-bound RAGE (mRAGE), and the soluble forms of RAGE (sRAGE), which comprise endogenous secretory RAGE (esRAGE) and an ectodomain-shed form of RAGE, and (4) oxytocin transporters in the brain and intestine, which are important for maternal bonding and social behaviors.
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spelling pubmed-88804222022-02-26 Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond Oshima, Yu Harashima, Ai Munesue, Seiichi Kimura, Kumi Leerach, Nontaphat Goto, Hisanori Tanaka, Mariko Niimura, Akane Hayashi, Kenjiro Yamamoto, Hiroshi Higashida, Haruhiro Yamamoto, Yasuhiko Int J Mol Sci Review Non-enzymatic glycation is an unavoidable reaction that occurs across biological taxa. The final products of this irreversible reaction are called advanced glycation end-products (AGEs). The endogenously formed AGEs are known to be bioactive and detrimental to human health. Additionally, exogenous food-derived AGEs are debated to contribute to the development of aging and various diseases. Receptor for AGEs (RAGE) is widely known to elicit biological reactions. The binding of RAGE to other ligands (e.g., high mobility group box 1, S100 proteins, lipopolysaccharides, and amyloid-β) can result in pathological processes via the activation of intracellular RAGE signaling pathways, including inflammation, diabetes, aging, cancer growth, and metastasis. RAGE is now recognized as a pattern-recognition receptor. All mammals have RAGE homologs; however, other vertebrates, such as birds, amphibians, fish, and reptiles, do not have RAGE at the genomic level. This evidence from an evolutionary perspective allows us to understand why mammals require RAGE. In this review, we provide an overview of the scientific knowledge about the role of RAGE in physiological and pathological processes. In particular, we focus on (1) RAGE biology, (2) the role of RAGE in physiological and pathophysiological processes, (3) RAGE isoforms, including full-length membrane-bound RAGE (mRAGE), and the soluble forms of RAGE (sRAGE), which comprise endogenous secretory RAGE (esRAGE) and an ectodomain-shed form of RAGE, and (4) oxytocin transporters in the brain and intestine, which are important for maternal bonding and social behaviors. MDPI 2022-02-14 /pmc/articles/PMC8880422/ /pubmed/35216202 http://dx.doi.org/10.3390/ijms23042086 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oshima, Yu
Harashima, Ai
Munesue, Seiichi
Kimura, Kumi
Leerach, Nontaphat
Goto, Hisanori
Tanaka, Mariko
Niimura, Akane
Hayashi, Kenjiro
Yamamoto, Hiroshi
Higashida, Haruhiro
Yamamoto, Yasuhiko
Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond
title Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond
title_full Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond
title_fullStr Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond
title_full_unstemmed Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond
title_short Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond
title_sort dual nature of rage in host reaction and nurturing the mother–infant bond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880422/
https://www.ncbi.nlm.nih.gov/pubmed/35216202
http://dx.doi.org/10.3390/ijms23042086
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