Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia

COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associat...

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Detalles Bibliográficos
Autores principales: Rubina, Kseniya, Shmakova, Anna, Shabanov, Aslan, Andreev, Yulii, Borovkova, Natalia, Kulabukhov, Vladimir, Evseev, Anatoliy, Popugaev, Konstantin, Petrikov, Sergey, Semina, Ekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880431/
https://www.ncbi.nlm.nih.gov/pubmed/35213582
http://dx.doi.org/10.1371/journal.pone.0264072
Descripción
Sumario:COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associated with high risk of COVID-19-related death outcome in the cohort of severely-ill patients in Russia. The data obtained reveal that elevated dead lymphocyte counts, decreased early apoptotic lymphocytes, decreased CD14+/HLA-Dr+ monocytes, increased expression of JNK in PBMCs, elevated IL-17 and decreased PAI-1 serum levels are associated with a high risk of COVID-19-related mortality thus suggesting them to be new prognostic factors. This set of determinants could be used as early predictors of potentially severe course of COVID-19 for trials of prevention or timely treatment.

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