Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling

Cobra cytotoxins (CTs) belong to the three-fingered protein family and possess membrane activity. Here, we studied cytotoxin 13 from Naja naja cobra venom (CT13Nn). For the first time, a spatial model of CT13Nn with both “water” and “membrane” conformations of the central loop (loop-2) were determin...

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Detalles Bibliográficos
Autores principales: Dubovskii, Peter V., Dubova, Kira M., Bourenkov, Gleb, Starkov, Vladislav G., Konshina, Anastasia G., Efremov, Roman G., Utkin, Yuri N., Samygina, Valeriya R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880459/
https://www.ncbi.nlm.nih.gov/pubmed/35202176
http://dx.doi.org/10.3390/toxins14020149

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