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Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases

Neurodegenerative diseases (NDs) mainly affect neurons and gradually lead to a loss of normal motor and cognitive functions. Atypical protein homeostasis—misfolding, aggregations and accumulations, oxidative stress, inflammation, and apoptosis—are common features in most NDs. To date, due to the com...

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Detalles Bibliográficos
Autores principales: Tan, Mario A., Sharma, Niti, An, Seong Soo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880493/
https://www.ncbi.nlm.nih.gov/pubmed/35215300
http://dx.doi.org/10.3390/ph15020188
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author Tan, Mario A.
Sharma, Niti
An, Seong Soo A.
author_facet Tan, Mario A.
Sharma, Niti
An, Seong Soo A.
author_sort Tan, Mario A.
collection PubMed
description Neurodegenerative diseases (NDs) mainly affect neurons and gradually lead to a loss of normal motor and cognitive functions. Atypical protein homeostasis—misfolding, aggregations and accumulations, oxidative stress, inflammation, and apoptosis—are common features in most NDs. To date, due to the complex etiology and pathogenesis of NDs, no defined treatment is available. There has been increasing interest in plant extracts as potential alternative medicines as the presence of various active components may exert synergistic and multi-pharmacological effects. Murraya koenigii (Rutaceae) is utilized in Ayurvedic medicine for various ailments. Pharmacological studies evidenced its potential antioxidant, anti-inflammatory, anticancer, hepatoprotective, immunomodulatory, antimicrobial, and neuroprotective activities, among others. In line with our interest in exploring natural agents for the treatment of neurodegenerative diseases, this review presents an overview of literature concerning the mechanisms of action and the safety profile of significant bioactive components present in M. koenigii leaves to support further investigations into their neuroprotective therapeutic potential.
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spelling pubmed-88804932022-02-26 Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases Tan, Mario A. Sharma, Niti An, Seong Soo A. Pharmaceuticals (Basel) Review Neurodegenerative diseases (NDs) mainly affect neurons and gradually lead to a loss of normal motor and cognitive functions. Atypical protein homeostasis—misfolding, aggregations and accumulations, oxidative stress, inflammation, and apoptosis—are common features in most NDs. To date, due to the complex etiology and pathogenesis of NDs, no defined treatment is available. There has been increasing interest in plant extracts as potential alternative medicines as the presence of various active components may exert synergistic and multi-pharmacological effects. Murraya koenigii (Rutaceae) is utilized in Ayurvedic medicine for various ailments. Pharmacological studies evidenced its potential antioxidant, anti-inflammatory, anticancer, hepatoprotective, immunomodulatory, antimicrobial, and neuroprotective activities, among others. In line with our interest in exploring natural agents for the treatment of neurodegenerative diseases, this review presents an overview of literature concerning the mechanisms of action and the safety profile of significant bioactive components present in M. koenigii leaves to support further investigations into their neuroprotective therapeutic potential. MDPI 2022-02-02 /pmc/articles/PMC8880493/ /pubmed/35215300 http://dx.doi.org/10.3390/ph15020188 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tan, Mario A.
Sharma, Niti
An, Seong Soo A.
Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases
title Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases
title_full Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases
title_fullStr Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases
title_full_unstemmed Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases
title_short Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases
title_sort multi-target approach of murraya koenigii leaves in treating neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880493/
https://www.ncbi.nlm.nih.gov/pubmed/35215300
http://dx.doi.org/10.3390/ph15020188
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