Metastasising Fibroblasts Show an HDAC6-Dependent Increase in Migration Speed and Loss of Directionality Linked to Major Changes in the Vimentin Interactome

Metastasising cells express the intermediate filament protein vimentin, which is used to diagnose invasive tumours in the clinic. We aimed to clarify how vimentin regulates the motility of metastasising fibroblasts. STED super-resolution microscopy, live-cell imaging and quantitative proteomics reve...

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Detalles Bibliográficos
Autores principales: Evans, Caroline A., Kim, Hyejeong Rosemary, Macfarlane, Sarah C., Nowicki, Poppy I. A., Baltes, Carsten, Xu, Lei, Widengren, Jerker, Lautenschläger, Franziska, Corfe, Bernard M., Gad, Annica K. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880509/
https://www.ncbi.nlm.nih.gov/pubmed/35216078
http://dx.doi.org/10.3390/ijms23041961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880509/
https://www.ncbi.nlm.nih.gov/pubmed/35216078
http://dx.doi.org/10.3390/ijms23041961

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