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Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development

An analysis of the literature generated within the past 20 year-span concerning risks of uterine fibroids (UFs) occurrence and dietary factors was carried out. A link between Vitamin D deficiency and UFs formation is strongly indicated, making it a potent compound in leiomyoma therapy. Analogs of th...

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Autores principales: Szydłowska, Iwona, Nawrocka-Rutkowska, Jolanta, Brodowska, Agnieszka, Marciniak, Aleksandra, Starczewski, Andrzej, Szczuko, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880543/
https://www.ncbi.nlm.nih.gov/pubmed/35215384
http://dx.doi.org/10.3390/nu14040734
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author Szydłowska, Iwona
Nawrocka-Rutkowska, Jolanta
Brodowska, Agnieszka
Marciniak, Aleksandra
Starczewski, Andrzej
Szczuko, Małgorzata
author_facet Szydłowska, Iwona
Nawrocka-Rutkowska, Jolanta
Brodowska, Agnieszka
Marciniak, Aleksandra
Starczewski, Andrzej
Szczuko, Małgorzata
author_sort Szydłowska, Iwona
collection PubMed
description An analysis of the literature generated within the past 20 year-span concerning risks of uterine fibroids (UFs) occurrence and dietary factors was carried out. A link between Vitamin D deficiency and UFs formation is strongly indicated, making it a potent compound in leiomyoma therapy. Analogs of the 25-hydroxyvitamin D3, not susceptible to degradation by tissue 24-hydroxylase, appear to be especially promising and tend to show better therapeutic results. Although research on the role of Vitamin A in the formation of fibroids is contradictory, Vitamin A-enriched diet, as well as synthetic retinoid analogues, may be preventative or limit the growth of fibroids. Unambiguous conclusions cannot be drawn regarding Vitamin E and C supplementation, except for alpha-tocopherol. Alpha-tocopherol as a phytoestrogen taking part in the modulation of estrogen receptors (ERs) involved in UF etiology, should be particularly avoided in therapy. A diet enriched in fruits and vegetables, as sources of carotenoids, polyphenols, quercetin, and indole-3-carbinol, constitutes an easily modifiable lifestyle element with beneficial results in patients with UFs. Other natural substances, such as curcumin, can reduce the oxidative stress and protect against inflammation in leiomyoma. Although the exact effect of probiotics on uterine fibroids has not yet been thoroughly evaluated at this point, the protective role of dairy products, i.e., yogurt consumption, has been indicated. Trace elements such as selenium can also contribute to antioxidative and anti-inflammatory properties of a recommended diet. In contrast, heavy metals, endocrine disrupting chemicals, cigarette smoking, and a diet low in antioxidants and fiber were, alongside genetic predispositions, associated with UFs formation.
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spelling pubmed-88805432022-02-26 Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development Szydłowska, Iwona Nawrocka-Rutkowska, Jolanta Brodowska, Agnieszka Marciniak, Aleksandra Starczewski, Andrzej Szczuko, Małgorzata Nutrients Review An analysis of the literature generated within the past 20 year-span concerning risks of uterine fibroids (UFs) occurrence and dietary factors was carried out. A link between Vitamin D deficiency and UFs formation is strongly indicated, making it a potent compound in leiomyoma therapy. Analogs of the 25-hydroxyvitamin D3, not susceptible to degradation by tissue 24-hydroxylase, appear to be especially promising and tend to show better therapeutic results. Although research on the role of Vitamin A in the formation of fibroids is contradictory, Vitamin A-enriched diet, as well as synthetic retinoid analogues, may be preventative or limit the growth of fibroids. Unambiguous conclusions cannot be drawn regarding Vitamin E and C supplementation, except for alpha-tocopherol. Alpha-tocopherol as a phytoestrogen taking part in the modulation of estrogen receptors (ERs) involved in UF etiology, should be particularly avoided in therapy. A diet enriched in fruits and vegetables, as sources of carotenoids, polyphenols, quercetin, and indole-3-carbinol, constitutes an easily modifiable lifestyle element with beneficial results in patients with UFs. Other natural substances, such as curcumin, can reduce the oxidative stress and protect against inflammation in leiomyoma. Although the exact effect of probiotics on uterine fibroids has not yet been thoroughly evaluated at this point, the protective role of dairy products, i.e., yogurt consumption, has been indicated. Trace elements such as selenium can also contribute to antioxidative and anti-inflammatory properties of a recommended diet. In contrast, heavy metals, endocrine disrupting chemicals, cigarette smoking, and a diet low in antioxidants and fiber were, alongside genetic predispositions, associated with UFs formation. MDPI 2022-02-09 /pmc/articles/PMC8880543/ /pubmed/35215384 http://dx.doi.org/10.3390/nu14040734 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szydłowska, Iwona
Nawrocka-Rutkowska, Jolanta
Brodowska, Agnieszka
Marciniak, Aleksandra
Starczewski, Andrzej
Szczuko, Małgorzata
Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development
title Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development
title_full Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development
title_fullStr Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development
title_full_unstemmed Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development
title_short Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development
title_sort dietary natural compounds and vitamins as potential cofactors in uterine fibroids growth and development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880543/
https://www.ncbi.nlm.nih.gov/pubmed/35215384
http://dx.doi.org/10.3390/nu14040734
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