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Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy
Due to increased exposure to ultraviolet radiation caused by increased outdoor activities, the incidence of skin cancer is increasing. Incision is the most typical method for treating skin cancer, and various treatments that can minimize the risks of incision surgery are being investigated. Among th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880560/ https://www.ncbi.nlm.nih.gov/pubmed/35214586 http://dx.doi.org/10.3390/s22041671 |
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author | Kim, Donghyuk Kim, Hyunjung |
author_facet | Kim, Donghyuk Kim, Hyunjung |
author_sort | Kim, Donghyuk |
collection | PubMed |
description | Due to increased exposure to ultraviolet radiation caused by increased outdoor activities, the incidence of skin cancer is increasing. Incision is the most typical method for treating skin cancer, and various treatments that can minimize the risks of incision surgery are being investigated. Among them, photothermal therapy is garnering attention because it does not cause bleeding and affords rapid recovery. In photothermal therapy, tumor death is induced via temperature increase. In this study, a numerical study based on heat transfer theory was conducted to investigate the death of squamous cell carcinoma located in the skin layer based on various shapes of gold nanoparticles (AuNPs) used in photothermal therapy. The quantitative correlation between the conditions of various AuNPs and the laser intensity that yields the optimal photothermal treatment effect was derived using the effective apoptosis ratio. It was confirmed that optimal conditions exist for maximizing apoptosis within a tumor tissue and minimizing the thermal damage to surrounding normal tissues when using AuNPs under various conditions. Furthermore, it is envisioned that research result will be utilized as a standard for photothermal treatment in the future. |
format | Online Article Text |
id | pubmed-8880560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88805602022-02-26 Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy Kim, Donghyuk Kim, Hyunjung Sensors (Basel) Article Due to increased exposure to ultraviolet radiation caused by increased outdoor activities, the incidence of skin cancer is increasing. Incision is the most typical method for treating skin cancer, and various treatments that can minimize the risks of incision surgery are being investigated. Among them, photothermal therapy is garnering attention because it does not cause bleeding and affords rapid recovery. In photothermal therapy, tumor death is induced via temperature increase. In this study, a numerical study based on heat transfer theory was conducted to investigate the death of squamous cell carcinoma located in the skin layer based on various shapes of gold nanoparticles (AuNPs) used in photothermal therapy. The quantitative correlation between the conditions of various AuNPs and the laser intensity that yields the optimal photothermal treatment effect was derived using the effective apoptosis ratio. It was confirmed that optimal conditions exist for maximizing apoptosis within a tumor tissue and minimizing the thermal damage to surrounding normal tissues when using AuNPs under various conditions. Furthermore, it is envisioned that research result will be utilized as a standard for photothermal treatment in the future. MDPI 2022-02-21 /pmc/articles/PMC8880560/ /pubmed/35214586 http://dx.doi.org/10.3390/s22041671 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Donghyuk Kim, Hyunjung Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy |
title | Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy |
title_full | Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy |
title_fullStr | Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy |
title_full_unstemmed | Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy |
title_short | Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy |
title_sort | numerical study on death of squamous cell carcinoma based on various shapes of gold nanoparticles using photothermal therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880560/ https://www.ncbi.nlm.nih.gov/pubmed/35214586 http://dx.doi.org/10.3390/s22041671 |
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