Cargando…

Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy

Due to increased exposure to ultraviolet radiation caused by increased outdoor activities, the incidence of skin cancer is increasing. Incision is the most typical method for treating skin cancer, and various treatments that can minimize the risks of incision surgery are being investigated. Among th...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Donghyuk, Kim, Hyunjung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880560/
https://www.ncbi.nlm.nih.gov/pubmed/35214586
http://dx.doi.org/10.3390/s22041671
_version_ 1784659243061739520
author Kim, Donghyuk
Kim, Hyunjung
author_facet Kim, Donghyuk
Kim, Hyunjung
author_sort Kim, Donghyuk
collection PubMed
description Due to increased exposure to ultraviolet radiation caused by increased outdoor activities, the incidence of skin cancer is increasing. Incision is the most typical method for treating skin cancer, and various treatments that can minimize the risks of incision surgery are being investigated. Among them, photothermal therapy is garnering attention because it does not cause bleeding and affords rapid recovery. In photothermal therapy, tumor death is induced via temperature increase. In this study, a numerical study based on heat transfer theory was conducted to investigate the death of squamous cell carcinoma located in the skin layer based on various shapes of gold nanoparticles (AuNPs) used in photothermal therapy. The quantitative correlation between the conditions of various AuNPs and the laser intensity that yields the optimal photothermal treatment effect was derived using the effective apoptosis ratio. It was confirmed that optimal conditions exist for maximizing apoptosis within a tumor tissue and minimizing the thermal damage to surrounding normal tissues when using AuNPs under various conditions. Furthermore, it is envisioned that research result will be utilized as a standard for photothermal treatment in the future.
format Online
Article
Text
id pubmed-8880560
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88805602022-02-26 Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy Kim, Donghyuk Kim, Hyunjung Sensors (Basel) Article Due to increased exposure to ultraviolet radiation caused by increased outdoor activities, the incidence of skin cancer is increasing. Incision is the most typical method for treating skin cancer, and various treatments that can minimize the risks of incision surgery are being investigated. Among them, photothermal therapy is garnering attention because it does not cause bleeding and affords rapid recovery. In photothermal therapy, tumor death is induced via temperature increase. In this study, a numerical study based on heat transfer theory was conducted to investigate the death of squamous cell carcinoma located in the skin layer based on various shapes of gold nanoparticles (AuNPs) used in photothermal therapy. The quantitative correlation between the conditions of various AuNPs and the laser intensity that yields the optimal photothermal treatment effect was derived using the effective apoptosis ratio. It was confirmed that optimal conditions exist for maximizing apoptosis within a tumor tissue and minimizing the thermal damage to surrounding normal tissues when using AuNPs under various conditions. Furthermore, it is envisioned that research result will be utilized as a standard for photothermal treatment in the future. MDPI 2022-02-21 /pmc/articles/PMC8880560/ /pubmed/35214586 http://dx.doi.org/10.3390/s22041671 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Donghyuk
Kim, Hyunjung
Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy
title Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy
title_full Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy
title_fullStr Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy
title_full_unstemmed Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy
title_short Numerical Study on Death of Squamous Cell Carcinoma Based on Various Shapes of Gold Nanoparticles Using Photothermal Therapy
title_sort numerical study on death of squamous cell carcinoma based on various shapes of gold nanoparticles using photothermal therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880560/
https://www.ncbi.nlm.nih.gov/pubmed/35214586
http://dx.doi.org/10.3390/s22041671
work_keys_str_mv AT kimdonghyuk numericalstudyondeathofsquamouscellcarcinomabasedonvariousshapesofgoldnanoparticlesusingphotothermaltherapy
AT kimhyunjung numericalstudyondeathofsquamouscellcarcinomabasedonvariousshapesofgoldnanoparticlesusingphotothermaltherapy