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In-Silico Screening of Novel Synthesized Thienopyrimidines Targeting Fms Related Receptor Tyrosine Kinase-3 and Their In-Vitro Biological Evaluation
The present investigation describes the design strategy and synthesis of novel thienopyrimidine compounds in addition to their anticancer activity targeting tyrosine kinase FLT3 enzyme. The synthesized compounds were subjected to a cytotoxic study where compounds 9a and 9b showed the most potent cyt...
Autores principales: | Elmongy, Elshaymaa I., Altwaijry, Najla, Attallah, Nashwah G. M., AlKahtani, Manal Mubarak, Henidi, Hanan Ali |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880588/ https://www.ncbi.nlm.nih.gov/pubmed/35215283 http://dx.doi.org/10.3390/ph15020170 |
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