Cargando…

Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

Scientists often set ambitious targets using environmental metabolomics to address challenging ecotoxicological issues. This promising approach has a high potential to elucidate the mechanisms of action (MeOAs) of contaminants (in hazard assessments) and to develop biomarkers (in environmental biomo...

Descripción completa

Detalles Bibliográficos
Autores principales: Dumas, Thibaut, Courant, Frédérique, Fenet, Hélène, Gomez, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880617/
https://www.ncbi.nlm.nih.gov/pubmed/35208259
http://dx.doi.org/10.3390/metabo12020186
_version_ 1784659258017579008
author Dumas, Thibaut
Courant, Frédérique
Fenet, Hélène
Gomez, Elena
author_facet Dumas, Thibaut
Courant, Frédérique
Fenet, Hélène
Gomez, Elena
author_sort Dumas, Thibaut
collection PubMed
description Scientists often set ambitious targets using environmental metabolomics to address challenging ecotoxicological issues. This promising approach has a high potential to elucidate the mechanisms of action (MeOAs) of contaminants (in hazard assessments) and to develop biomarkers (in environmental biomonitoring). However, metabolomics fingerprints often involve a complex mixture of molecular effects that are hard to link to a specific MeOA (if detected in the analytical conditions used). Given these promises and limitations, here we propose an updated review on the achievements of this approach. Metabolomics-based studies conducted on the effects of pharmaceutical active compounds in aquatic organisms provide a relevant means to review the achievements of this approach, as prior knowledge about the MeOA of these molecules could help overcome some shortcomings. This review highlighted that current metabolomics advances have enabled more accurate MeOA assessment, especially when combined with other omics approaches. The combination of metabolomics with other measured biological endpoints has also turned out to be an efficient way to link molecular effects to (sub)-individual adverse outcomes, thereby paving the way to the construction of adverse outcome pathways (AOPs). Here, we also discuss the importance of determining MeOA as a key strategy in the identification of MeOA-specific biomarkers for biomonitoring. We have put forward some recommendations to take full advantage of environmental metabolomics and thus help fulfil these promises.
format Online
Article
Text
id pubmed-8880617
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88806172022-02-26 Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens Dumas, Thibaut Courant, Frédérique Fenet, Hélène Gomez, Elena Metabolites Review Scientists often set ambitious targets using environmental metabolomics to address challenging ecotoxicological issues. This promising approach has a high potential to elucidate the mechanisms of action (MeOAs) of contaminants (in hazard assessments) and to develop biomarkers (in environmental biomonitoring). However, metabolomics fingerprints often involve a complex mixture of molecular effects that are hard to link to a specific MeOA (if detected in the analytical conditions used). Given these promises and limitations, here we propose an updated review on the achievements of this approach. Metabolomics-based studies conducted on the effects of pharmaceutical active compounds in aquatic organisms provide a relevant means to review the achievements of this approach, as prior knowledge about the MeOA of these molecules could help overcome some shortcomings. This review highlighted that current metabolomics advances have enabled more accurate MeOA assessment, especially when combined with other omics approaches. The combination of metabolomics with other measured biological endpoints has also turned out to be an efficient way to link molecular effects to (sub)-individual adverse outcomes, thereby paving the way to the construction of adverse outcome pathways (AOPs). Here, we also discuss the importance of determining MeOA as a key strategy in the identification of MeOA-specific biomarkers for biomonitoring. We have put forward some recommendations to take full advantage of environmental metabolomics and thus help fulfil these promises. MDPI 2022-02-17 /pmc/articles/PMC8880617/ /pubmed/35208259 http://dx.doi.org/10.3390/metabo12020186 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dumas, Thibaut
Courant, Frédérique
Fenet, Hélène
Gomez, Elena
Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens
title Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens
title_full Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens
title_fullStr Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens
title_full_unstemmed Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens
title_short Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens
title_sort environmental metabolomics promises and achievements in the field of aquatic ecotoxicology: viewed through the pharmaceutical lens
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880617/
https://www.ncbi.nlm.nih.gov/pubmed/35208259
http://dx.doi.org/10.3390/metabo12020186
work_keys_str_mv AT dumasthibaut environmentalmetabolomicspromisesandachievementsinthefieldofaquaticecotoxicologyviewedthroughthepharmaceuticallens
AT courantfrederique environmentalmetabolomicspromisesandachievementsinthefieldofaquaticecotoxicologyviewedthroughthepharmaceuticallens
AT fenethelene environmentalmetabolomicspromisesandachievementsinthefieldofaquaticecotoxicologyviewedthroughthepharmaceuticallens
AT gomezelena environmentalmetabolomicspromisesandachievementsinthefieldofaquaticecotoxicologyviewedthroughthepharmaceuticallens