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Computational Design of High-Affinity Blockers for Sodium Channel Na(V)1.2 from μ-Conotoxin KIIIA
The voltage-gated sodium channel subtype 1.2 (Na(V)1.2) is instrumental in the initiation of action potentials in the nervous system, making it a natural drug target for neurological diseases. Therefore, there is much pharmacological interest in finding blockers of Na(V)1.2 and improving their affin...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880641/ https://www.ncbi.nlm.nih.gov/pubmed/35200683 http://dx.doi.org/10.3390/md20020154 |