The Tetrahydrofuran Motif in Polyketide Marine Drugs

Oxygen heterocycles are units that are abundant in a great number of marine natural products. Among them, marine polyketides containing tetrahydrofuran rings have attracted great attention within the scientific community due to their challenging structures and promising biological activities. An ove...

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Detalles Bibliográficos
Autores principales: Fernández-Peña, Laura, Díez-Poza, Carlos, González-Andrés, Paula, Barbero, Asunción
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880653/
https://www.ncbi.nlm.nih.gov/pubmed/35200649
http://dx.doi.org/10.3390/md20020120
Descripción
Sumario:Oxygen heterocycles are units that are abundant in a great number of marine natural products. Among them, marine polyketides containing tetrahydrofuran rings have attracted great attention within the scientific community due to their challenging structures and promising biological activities. An overview of the most important marine tetrahydrofuran polyketides, with a focused discussion on their isolation, structure determination, approaches to their total synthesis, and biological studies is provided.

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