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Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study

(1) Background: Mangiferin (MGN) is a natural compound, showing anti-inflammatory and antioxidant activities for the potential treatment of eye diseases. The poor physicochemical features of MGN (low solubility and high instability) justify its nanoencapsulation into nanostructured lipid carriers (N...

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Autores principales: Santonocito, Debora, Vivero-Lopez, Maria, Lauro, Maria Rosaria, Torrisi, Cristina, Castelli, Francesco, Sarpietro, Maria Grazia, Puglia, Carmelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880740/
https://www.ncbi.nlm.nih.gov/pubmed/35209120
http://dx.doi.org/10.3390/molecules27041328
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author Santonocito, Debora
Vivero-Lopez, Maria
Lauro, Maria Rosaria
Torrisi, Cristina
Castelli, Francesco
Sarpietro, Maria Grazia
Puglia, Carmelo
author_facet Santonocito, Debora
Vivero-Lopez, Maria
Lauro, Maria Rosaria
Torrisi, Cristina
Castelli, Francesco
Sarpietro, Maria Grazia
Puglia, Carmelo
author_sort Santonocito, Debora
collection PubMed
description (1) Background: Mangiferin (MGN) is a natural compound, showing anti-inflammatory and antioxidant activities for the potential treatment of eye diseases. The poor physicochemical features of MGN (low solubility and high instability) justify its nanoencapsulation into nanostructured lipid carriers (NLC) to improve its ocular bioavailability. (2) Methods: Firstly, MGN-NLC were prepared by the high shear homogenization coupled with the ultrasound (HSH−US) method. Finally, unloaded and MGN-loaded NLC were analyzed in terms of ocular tolerance. (3) Results: MGN-NLC showed good technological parameters suitable for ocular administration (particle size below 200 nm). The ORAC assay was performed to quantify the antioxidant activity of MGN, showing that the antioxidant activity of MGN-NLC (6494 ± 186 μM TE/g) was higher than that of the free compound (3521 ± 271 μM TE/g). This confirmed that the encapsulation of the drug was able to preserve and increase its activity. In ovo studies (HET-CAM) revealed that the formulation can be considered nonirritant. (4) Conclusions: Therefore, NLC systems are a promising approach for the ocular delivery of MGN.
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spelling pubmed-88807402022-02-26 Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study Santonocito, Debora Vivero-Lopez, Maria Lauro, Maria Rosaria Torrisi, Cristina Castelli, Francesco Sarpietro, Maria Grazia Puglia, Carmelo Molecules Article (1) Background: Mangiferin (MGN) is a natural compound, showing anti-inflammatory and antioxidant activities for the potential treatment of eye diseases. The poor physicochemical features of MGN (low solubility and high instability) justify its nanoencapsulation into nanostructured lipid carriers (NLC) to improve its ocular bioavailability. (2) Methods: Firstly, MGN-NLC were prepared by the high shear homogenization coupled with the ultrasound (HSH−US) method. Finally, unloaded and MGN-loaded NLC were analyzed in terms of ocular tolerance. (3) Results: MGN-NLC showed good technological parameters suitable for ocular administration (particle size below 200 nm). The ORAC assay was performed to quantify the antioxidant activity of MGN, showing that the antioxidant activity of MGN-NLC (6494 ± 186 μM TE/g) was higher than that of the free compound (3521 ± 271 μM TE/g). This confirmed that the encapsulation of the drug was able to preserve and increase its activity. In ovo studies (HET-CAM) revealed that the formulation can be considered nonirritant. (4) Conclusions: Therefore, NLC systems are a promising approach for the ocular delivery of MGN. MDPI 2022-02-16 /pmc/articles/PMC8880740/ /pubmed/35209120 http://dx.doi.org/10.3390/molecules27041328 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Santonocito, Debora
Vivero-Lopez, Maria
Lauro, Maria Rosaria
Torrisi, Cristina
Castelli, Francesco
Sarpietro, Maria Grazia
Puglia, Carmelo
Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study
title Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study
title_full Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study
title_fullStr Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study
title_full_unstemmed Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study
title_short Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study
title_sort design of nanotechnological carriers for ocular delivery of mangiferin: preformulation study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880740/
https://www.ncbi.nlm.nih.gov/pubmed/35209120
http://dx.doi.org/10.3390/molecules27041328
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