Cargando…

Production of Bioactive Substances to Alleviates Hangover and Ethanol-Induced Liver Damage through Fermentation of Oenanthe javanica Using Lactiplantibacillus plantarum

The purpose of this study is to evaluate the effect of the bioconversion products of Oenanthe javanica extract fermented by Lactiplantibacillus plantarum (OEFL) on relieving hangovers and improving liver function. In addition, the bioactive substance of the OEFL, which alleviates hangover and ethano...

Descripción completa

Detalles Bibliográficos
Autores principales: Gam, Da Hye, Park, Jae Hyun, Kim, So Hee, Kang, Min Ho, Kim, Se Bin, Kim, Jin Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880744/
https://www.ncbi.nlm.nih.gov/pubmed/35208964
http://dx.doi.org/10.3390/molecules27041175
_version_ 1784659295713886208
author Gam, Da Hye
Park, Jae Hyun
Kim, So Hee
Kang, Min Ho
Kim, Se Bin
Kim, Jin Woo
author_facet Gam, Da Hye
Park, Jae Hyun
Kim, So Hee
Kang, Min Ho
Kim, Se Bin
Kim, Jin Woo
author_sort Gam, Da Hye
collection PubMed
description The purpose of this study is to evaluate the effect of the bioconversion products of Oenanthe javanica extract fermented by Lactiplantibacillus plantarum (OEFL) on relieving hangovers and improving liver function. In addition, the bioactive substance of the OEFL, which alleviates hangover and ethanol-induced liver damage, was identified and its bioactive property was verified through in vivo experiments. In major substances analysis using high-performance liquid chromatography, OEFL produced 9.5-fold higher p-coumaric acid than the O. Javanica extract (OE). In addition, considering that quinic acid, which is not present in the OE, was produced in the OEFL it was confirmed that chlorogenic acid was decomposed into quinic acid by bioconversion. In the in vivo experiment using Sprague-Dawley rats, the OEFL and p-coumaric acid diets reduced blood ethanol, acetaldehyde, GPT, and ALP concentrations, increasing blood albumin concentrations compared to ethanol-administered groups, demonstrating that OEFL and p-coumaric acid, the main substance in the OEFL, improved ethanol-induced liver damage. Furthermore, the OEFL and its main bioactive substance, p-coumaric acid, alleviated liver fibrosis by downregulating TGF-β, SMAD-2, SMAD-4, α-SMA, and upregulating MMP-1. Therefore, OEFL is expected to be used as a functional food or pharmaceutical material as it has been confirmed to effectively relieve hangovers, prevent liver damage, and delay liver fibrosis in ethanol-induced liver damages.
format Online
Article
Text
id pubmed-8880744
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88807442022-02-26 Production of Bioactive Substances to Alleviates Hangover and Ethanol-Induced Liver Damage through Fermentation of Oenanthe javanica Using Lactiplantibacillus plantarum Gam, Da Hye Park, Jae Hyun Kim, So Hee Kang, Min Ho Kim, Se Bin Kim, Jin Woo Molecules Article The purpose of this study is to evaluate the effect of the bioconversion products of Oenanthe javanica extract fermented by Lactiplantibacillus plantarum (OEFL) on relieving hangovers and improving liver function. In addition, the bioactive substance of the OEFL, which alleviates hangover and ethanol-induced liver damage, was identified and its bioactive property was verified through in vivo experiments. In major substances analysis using high-performance liquid chromatography, OEFL produced 9.5-fold higher p-coumaric acid than the O. Javanica extract (OE). In addition, considering that quinic acid, which is not present in the OE, was produced in the OEFL it was confirmed that chlorogenic acid was decomposed into quinic acid by bioconversion. In the in vivo experiment using Sprague-Dawley rats, the OEFL and p-coumaric acid diets reduced blood ethanol, acetaldehyde, GPT, and ALP concentrations, increasing blood albumin concentrations compared to ethanol-administered groups, demonstrating that OEFL and p-coumaric acid, the main substance in the OEFL, improved ethanol-induced liver damage. Furthermore, the OEFL and its main bioactive substance, p-coumaric acid, alleviated liver fibrosis by downregulating TGF-β, SMAD-2, SMAD-4, α-SMA, and upregulating MMP-1. Therefore, OEFL is expected to be used as a functional food or pharmaceutical material as it has been confirmed to effectively relieve hangovers, prevent liver damage, and delay liver fibrosis in ethanol-induced liver damages. MDPI 2022-02-09 /pmc/articles/PMC8880744/ /pubmed/35208964 http://dx.doi.org/10.3390/molecules27041175 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gam, Da Hye
Park, Jae Hyun
Kim, So Hee
Kang, Min Ho
Kim, Se Bin
Kim, Jin Woo
Production of Bioactive Substances to Alleviates Hangover and Ethanol-Induced Liver Damage through Fermentation of Oenanthe javanica Using Lactiplantibacillus plantarum
title Production of Bioactive Substances to Alleviates Hangover and Ethanol-Induced Liver Damage through Fermentation of Oenanthe javanica Using Lactiplantibacillus plantarum
title_full Production of Bioactive Substances to Alleviates Hangover and Ethanol-Induced Liver Damage through Fermentation of Oenanthe javanica Using Lactiplantibacillus plantarum
title_fullStr Production of Bioactive Substances to Alleviates Hangover and Ethanol-Induced Liver Damage through Fermentation of Oenanthe javanica Using Lactiplantibacillus plantarum
title_full_unstemmed Production of Bioactive Substances to Alleviates Hangover and Ethanol-Induced Liver Damage through Fermentation of Oenanthe javanica Using Lactiplantibacillus plantarum
title_short Production of Bioactive Substances to Alleviates Hangover and Ethanol-Induced Liver Damage through Fermentation of Oenanthe javanica Using Lactiplantibacillus plantarum
title_sort production of bioactive substances to alleviates hangover and ethanol-induced liver damage through fermentation of oenanthe javanica using lactiplantibacillus plantarum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880744/
https://www.ncbi.nlm.nih.gov/pubmed/35208964
http://dx.doi.org/10.3390/molecules27041175
work_keys_str_mv AT gamdahye productionofbioactivesubstancestoalleviateshangoverandethanolinducedliverdamagethroughfermentationofoenanthejavanicausinglactiplantibacillusplantarum
AT parkjaehyun productionofbioactivesubstancestoalleviateshangoverandethanolinducedliverdamagethroughfermentationofoenanthejavanicausinglactiplantibacillusplantarum
AT kimsohee productionofbioactivesubstancestoalleviateshangoverandethanolinducedliverdamagethroughfermentationofoenanthejavanicausinglactiplantibacillusplantarum
AT kangminho productionofbioactivesubstancestoalleviateshangoverandethanolinducedliverdamagethroughfermentationofoenanthejavanicausinglactiplantibacillusplantarum
AT kimsebin productionofbioactivesubstancestoalleviateshangoverandethanolinducedliverdamagethroughfermentationofoenanthejavanicausinglactiplantibacillusplantarum
AT kimjinwoo productionofbioactivesubstancestoalleviateshangoverandethanolinducedliverdamagethroughfermentationofoenanthejavanicausinglactiplantibacillusplantarum