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Persistent Fibroadipogenic Progenitor Expansion Following Transient DUX4 Expression Provokes a Profibrotic State in a Mouse Model for FSHD

FSHD is caused by loss of silencing of the DUX4 gene, but the DUX4 protein has not yet been directly detected immunohistologically in affected muscle, raising the possibility that DUX4 expression may occur at time points prior to obtaining adult biopsies for analysis, with consequent perturbations o...

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Detalles Bibliográficos
Autores principales:	Bosnakovski, Darko, Oyler, David, Mitanoska, Ana, Douglas, Madison, Ener, Elizabeth T., Shams, Ahmed S., Kyba, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880758/ https://www.ncbi.nlm.nih.gov/pubmed/35216102 http://dx.doi.org/10.3390/ijms23041983

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