Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism

GITR is a TNF receptor, and its activation promotes immune responses and drives antitumor activity. The receptor is activated by the GITR ligand (GITRL), which is believed to cluster receptors into a high-order array. Immunotherapeutic agonist antibodies also activate the receptor, but their mechani...

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Detalles Bibliográficos
Autores principales: He, Changhao, Maniyar, Rachana R., Avraham, Yahel, Zappasodi, Roberta, Rusinova, Radda, Newman, Walter, Heath, Heidi, Wolchok, Jedd D., Dahan, Rony, Merghoub, Taha, Meyerson, Joel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880771/
https://www.ncbi.nlm.nih.gov/pubmed/35213218
http://dx.doi.org/10.1126/sciadv.abm4552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880771/
https://www.ncbi.nlm.nih.gov/pubmed/35213218
http://dx.doi.org/10.1126/sciadv.abm4552

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