Design and Experimental Evaluation of a Peptide Antagonist against Amyloid β(1–42) Interactions with Calmodulin and Calbindin-D28k

Amyloid β(1–42) (Aβ(1–42)) oligomers have been linked to the pathogenesis of Alzheimer’s disease (AD). Intracellular calcium (Ca(2+)) homeostasis dysregulation with subsequent alterations of neuronal excitability has been proposed to mediate Aβ neurotoxicity in AD. The Ca(2+) binding proteins calmod...

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Detalles Bibliográficos
Autores principales: Salazar, Jairo, Poejo, Joana, Mata, Ana M., Samhan-Arias, Alejandro K., Gutierrez-Merino, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880779/
https://www.ncbi.nlm.nih.gov/pubmed/35216403
http://dx.doi.org/10.3390/ijms23042289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880779/
https://www.ncbi.nlm.nih.gov/pubmed/35216403
http://dx.doi.org/10.3390/ijms23042289

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