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Early Experience with Salvage Robotic-Assisted Radical Prostatectomy in Proton Beam Radiotherapy Failures
AIMS: To assess the perioperative and short-term functional and oncologic outcomes of the salvage robot-assisted radical prostatectomy (sRARP), after recurrence following primary proton beam therapy for clinically localized prostate cancer. METHODS: Ten patients undergoing sRARP after failure of the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Trakya University School of Medicine
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880822/ https://www.ncbi.nlm.nih.gov/pubmed/34462255 http://dx.doi.org/10.5152/balkanmedj.2021.21174 |
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author | Bozkurt, Yaşar Atar, Murat L. Pisters, Louis |
author_facet | Bozkurt, Yaşar Atar, Murat L. Pisters, Louis |
author_sort | Bozkurt, Yaşar |
collection | PubMed |
description | AIMS: To assess the perioperative and short-term functional and oncologic outcomes of the salvage robot-assisted radical prostatectomy (sRARP), after recurrence following primary proton beam therapy for clinically localized prostate cancer. METHODS: Ten patients undergoing sRARP after failure of the prior definitive proton beam therapy for localized prostate cancer were included. BCR is defined as a prostate-specific antigen (PSA) value of 2.0 ng/mL greater than the absolute nadir. All of the individuals had a diagnosis of prostate cancer via biopsy after proton beam therapy, with negative findings on magnetic resonance imaging/computer tomography of the pelvis and abdomen, and a bone scan. The sRARP procedure with pelvic lymph node dissection was performed by a single surgeon in all patients. RESULTS: The median age of the cohort at sRARP was 66.8 years, and the mean BMI was 29.2 kg/m(2). The mean duration from proton beam therapy to sRARP was 58.4 months; the mean preoperative PSA level was 5.5 ng/mL, the mean operative time was 230 minutes, and the approximate blood loss was 745 mL. Anastomotic leakage occurred in half of the individuals, and bladder neck contracture developed in 6 patients. For 8 patients, the continence results within 6 months follow-up were available. Overall, 24 complications occurred in 9 patients. At follow-up in the 32nd month, the overall survival rate was 80%, and the BCR-free survival rate was 90%. CONCLUSION: sRARP after proton beam therapy is an applicable procedure, but has a high risk of serious complications. |
format | Online Article Text |
id | pubmed-8880822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Trakya University School of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-88808222022-03-10 Early Experience with Salvage Robotic-Assisted Radical Prostatectomy in Proton Beam Radiotherapy Failures Bozkurt, Yaşar Atar, Murat L. Pisters, Louis Balkan Med J Brief Report AIMS: To assess the perioperative and short-term functional and oncologic outcomes of the salvage robot-assisted radical prostatectomy (sRARP), after recurrence following primary proton beam therapy for clinically localized prostate cancer. METHODS: Ten patients undergoing sRARP after failure of the prior definitive proton beam therapy for localized prostate cancer were included. BCR is defined as a prostate-specific antigen (PSA) value of 2.0 ng/mL greater than the absolute nadir. All of the individuals had a diagnosis of prostate cancer via biopsy after proton beam therapy, with negative findings on magnetic resonance imaging/computer tomography of the pelvis and abdomen, and a bone scan. The sRARP procedure with pelvic lymph node dissection was performed by a single surgeon in all patients. RESULTS: The median age of the cohort at sRARP was 66.8 years, and the mean BMI was 29.2 kg/m(2). The mean duration from proton beam therapy to sRARP was 58.4 months; the mean preoperative PSA level was 5.5 ng/mL, the mean operative time was 230 minutes, and the approximate blood loss was 745 mL. Anastomotic leakage occurred in half of the individuals, and bladder neck contracture developed in 6 patients. For 8 patients, the continence results within 6 months follow-up were available. Overall, 24 complications occurred in 9 patients. At follow-up in the 32nd month, the overall survival rate was 80%, and the BCR-free survival rate was 90%. CONCLUSION: sRARP after proton beam therapy is an applicable procedure, but has a high risk of serious complications. Trakya University School of Medicine 2021-09-01 /pmc/articles/PMC8880822/ /pubmed/34462255 http://dx.doi.org/10.5152/balkanmedj.2021.21174 Text en © Copyright 2021 authors https://creativecommons.org/licenses/by-nc-nd/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Brief Report Bozkurt, Yaşar Atar, Murat L. Pisters, Louis Early Experience with Salvage Robotic-Assisted Radical Prostatectomy in Proton Beam Radiotherapy Failures |
title | Early Experience with Salvage Robotic-Assisted Radical Prostatectomy in Proton Beam Radiotherapy Failures |
title_full | Early Experience with Salvage Robotic-Assisted Radical Prostatectomy in Proton Beam Radiotherapy Failures |
title_fullStr | Early Experience with Salvage Robotic-Assisted Radical Prostatectomy in Proton Beam Radiotherapy Failures |
title_full_unstemmed | Early Experience with Salvage Robotic-Assisted Radical Prostatectomy in Proton Beam Radiotherapy Failures |
title_short | Early Experience with Salvage Robotic-Assisted Radical Prostatectomy in Proton Beam Radiotherapy Failures |
title_sort | early experience with salvage robotic-assisted radical prostatectomy in proton beam radiotherapy failures |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880822/ https://www.ncbi.nlm.nih.gov/pubmed/34462255 http://dx.doi.org/10.5152/balkanmedj.2021.21174 |
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