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Blocking Kir6.2 channels with SpTx1 potentiates glucose-stimulated insulin secretion from murine pancreatic β cells and lowers blood glucose in diabetic mice

ATP-sensitive K(+) (K(ATP)) channels in pancreatic β cells are comprised of pore-forming subunits (Kir6.2) and modulatory sulfonylurea receptor subunits (SUR1). The ATP sensitivity of these channels enables them to couple metabolic state to insulin secretion in β cells. Antidiabetic sulfonylureas su...

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Detalles Bibliográficos
Autores principales:	Ramu, Yajamana, Yamakaze, Jayden, Zhou, Yufeng, Hoshi, Toshinori, Lu, Zhe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880991/ https://www.ncbi.nlm.nih.gov/pubmed/35212627 http://dx.doi.org/10.7554/eLife.77026

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