Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides

The organophosphorus antidotes, so-called oximes, are able to restore the enzymatic function of acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) via cleavage of organophosphate from the active site of the phosphylated enzyme. In this work, the charged pyridinium oximes containing thiocarb...

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Detalles Bibliográficos
Autores principales: Kohoutova, Zuzana, Malinak, David, Andrys, Rudolf, Svobodova, Jana, Psotka, Miroslav, Schmidt, Monika, Prchal, Lukas, Musilek, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881075/
https://www.ncbi.nlm.nih.gov/pubmed/35193448
http://dx.doi.org/10.1080/14756366.2022.2041628

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