Cargando…
Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population
AIMS: Coronary artery disease (CAD) represents the leading cause of death worldwide. Accumulating evidence also suggests that sirtuins (SIRTS) have been associated with CAD. The present study was aimed at investigating the association between 12 gene polymorphisms for SIRTs and the development of CA...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881115/ https://www.ncbi.nlm.nih.gov/pubmed/35224092 http://dx.doi.org/10.1155/2022/4294008 |
_version_ | 1784659387362574336 |
---|---|
author | Song, Xingfa Wang, Haidong Wang, Chao Ji, Guangquan Jiang, Pei Liang, Donglou Wang, Xiaojing |
author_facet | Song, Xingfa Wang, Haidong Wang, Chao Ji, Guangquan Jiang, Pei Liang, Donglou Wang, Xiaojing |
author_sort | Song, Xingfa |
collection | PubMed |
description | AIMS: Coronary artery disease (CAD) represents the leading cause of death worldwide. Accumulating evidence also suggests that sirtuins (SIRTS) have been associated with CAD. The present study was aimed at investigating the association between 12 gene polymorphisms for SIRTs and the development of CAD in a Chinese population. MATERIALS AND METHODS: 12 SNPs (rs12778366 (T > C), rs3758391 (T > C), rs3740051 (A > G), rs4746720 (C > T), rs7895833 (G > A), rs932658 (A > C) for SIRT1, rs2015 (G > T) for SIRT2, rs28365927 (G > A), rs11246020 (C > T) for SIRT3, rs350844 (G > A), rs350846 (G > C), and rs107251 (C > T) for SIRT6) were selected and assessed in a cohort of 509 CAD patients and 552 matched healthy controls for this study. Genomic DNA from whole blood was extracted, and the SNPs were assessed using MassARRAY method. RESULTS: TT genotype for rs3758391 and GG genotype for rs7895833 of SIRT1 were at higher risk of CAD, whereas the CC genotype for rs4746720 of SIRT1 was associated with a significantly decreased risk of CAD. The A allele of the rs28365927 of SIRT3 showed a significant decreased risk association with CAD patient group (P = 0.014). Significant difference in genotypes rs350844 (G > A) (P = 0.004), rs350846 (G > C) (P = 0.002), and rs107251 (C > T) (P ≤ 0.01) for SIRT6 was also found between the CAD patients and the healthy controls. Haplotype CTA significantly increased the risk of CAD (P = 0.000118, OR = 1.497, 95%CI = 1.218–1.840), while haplotype GCG significantly decreases the risk of CAD (P = 0.000414, OR = 1.131, 95%CI = 0.791–1.619). CONCLUSIONS: The SNP rs28365927 in the SIRT3 gene and SNP rs350844, rs350846, and rs107251 in the SIRT6 gene present significant associations with CAD in a north Chinese population. Haplotype CTA and GCG generated by rs350846/rs107251/rs350844 in the SIRT6 might also increase and decrease the risk of CAD, respectively. |
format | Online Article Text |
id | pubmed-8881115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-88811152022-02-26 Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population Song, Xingfa Wang, Haidong Wang, Chao Ji, Guangquan Jiang, Pei Liang, Donglou Wang, Xiaojing Biomed Res Int Research Article AIMS: Coronary artery disease (CAD) represents the leading cause of death worldwide. Accumulating evidence also suggests that sirtuins (SIRTS) have been associated with CAD. The present study was aimed at investigating the association between 12 gene polymorphisms for SIRTs and the development of CAD in a Chinese population. MATERIALS AND METHODS: 12 SNPs (rs12778366 (T > C), rs3758391 (T > C), rs3740051 (A > G), rs4746720 (C > T), rs7895833 (G > A), rs932658 (A > C) for SIRT1, rs2015 (G > T) for SIRT2, rs28365927 (G > A), rs11246020 (C > T) for SIRT3, rs350844 (G > A), rs350846 (G > C), and rs107251 (C > T) for SIRT6) were selected and assessed in a cohort of 509 CAD patients and 552 matched healthy controls for this study. Genomic DNA from whole blood was extracted, and the SNPs were assessed using MassARRAY method. RESULTS: TT genotype for rs3758391 and GG genotype for rs7895833 of SIRT1 were at higher risk of CAD, whereas the CC genotype for rs4746720 of SIRT1 was associated with a significantly decreased risk of CAD. The A allele of the rs28365927 of SIRT3 showed a significant decreased risk association with CAD patient group (P = 0.014). Significant difference in genotypes rs350844 (G > A) (P = 0.004), rs350846 (G > C) (P = 0.002), and rs107251 (C > T) (P ≤ 0.01) for SIRT6 was also found between the CAD patients and the healthy controls. Haplotype CTA significantly increased the risk of CAD (P = 0.000118, OR = 1.497, 95%CI = 1.218–1.840), while haplotype GCG significantly decreases the risk of CAD (P = 0.000414, OR = 1.131, 95%CI = 0.791–1.619). CONCLUSIONS: The SNP rs28365927 in the SIRT3 gene and SNP rs350844, rs350846, and rs107251 in the SIRT6 gene present significant associations with CAD in a north Chinese population. Haplotype CTA and GCG generated by rs350846/rs107251/rs350844 in the SIRT6 might also increase and decrease the risk of CAD, respectively. Hindawi 2022-02-18 /pmc/articles/PMC8881115/ /pubmed/35224092 http://dx.doi.org/10.1155/2022/4294008 Text en Copyright © 2022 Xingfa Song et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Song, Xingfa Wang, Haidong Wang, Chao Ji, Guangquan Jiang, Pei Liang, Donglou Wang, Xiaojing Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population |
title | Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population |
title_full | Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population |
title_fullStr | Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population |
title_full_unstemmed | Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population |
title_short | Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population |
title_sort | association of sirtuin gene polymorphisms with susceptibility to coronary artery disease in a north chinese population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881115/ https://www.ncbi.nlm.nih.gov/pubmed/35224092 http://dx.doi.org/10.1155/2022/4294008 |
work_keys_str_mv | AT songxingfa associationofsirtuingenepolymorphismswithsusceptibilitytocoronaryarterydiseaseinanorthchinesepopulation AT wanghaidong associationofsirtuingenepolymorphismswithsusceptibilitytocoronaryarterydiseaseinanorthchinesepopulation AT wangchao associationofsirtuingenepolymorphismswithsusceptibilitytocoronaryarterydiseaseinanorthchinesepopulation AT jiguangquan associationofsirtuingenepolymorphismswithsusceptibilitytocoronaryarterydiseaseinanorthchinesepopulation AT jiangpei associationofsirtuingenepolymorphismswithsusceptibilitytocoronaryarterydiseaseinanorthchinesepopulation AT liangdonglou associationofsirtuingenepolymorphismswithsusceptibilitytocoronaryarterydiseaseinanorthchinesepopulation AT wangxiaojing associationofsirtuingenepolymorphismswithsusceptibilitytocoronaryarterydiseaseinanorthchinesepopulation |