Cargando…

Nrf2 Deficiency Attenuates Testosterone Efficiency in Ameliorating Mitochondrial Function of the Substantia Nigra in Aged Male Mice

Reduced testosterone level is a common feature of aging in men. Aging, as a risk factor for several neurodegenerative disorders, shows declined mitochondrial function and downregulated mitochondrial biogenesis and mitochondrial dynamics. Mitochondrial biogenesis and mitochondrial dynamics are crucia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Baoliang, Zhang, Tianyun, Guo, Qiqing, Che, Jing, Kang, Yunxiao, Cui, Rui, Wang, Yu, Ji, Xiaoming, Zhang, Guoliang, Shi, Geming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881137/ https://www.ncbi.nlm.nih.gov/pubmed/35222795 http://dx.doi.org/10.1155/2022/3644318

Ejemplares similares

Testosterone enhances mitochondrial complex V function in the substantia nigra of aged male rats
por: Zhang, Tianyun, et al.
Publicado: (2020)

Testosterone propionate activated the Nrf2-ARE pathway in ageing rats and ameliorated the age-related changes in liver
por: Zhang, Guoliang, et al.
Publicado: (2019)

LncRNAs down-regulate Myh1, Casr, and Mis18a expression in the Substantia Nigra of aged male rats
por: Zhang, Guoliang, et al.
Publicado: (2019)

Testosterone ameliorates age-related brain mitochondrial dysfunction
por: Yan, Wensheng, et al.
Publicado: (2021)

Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats
por: Cui, Rui, et al.
Publicado: (2017)

Soemmerring and the Substantia Nigra
por: Faull, R. L. M, et al.
Publicado: (1968)

Glucocerebrosidase Deficiency in Substantia Nigra of Parkinson Disease Brains
por: Gegg, Matthew E, et al.
Publicado: (2012)

Amelioratory Effects of Testosterone Propionate on Age-related Renal Fibrosis via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2-ARE Signaling
por: Zhang, Guoliang, et al.
Publicado: (2018)

Pentoxifylline Enhances Antioxidative Capability and Promotes Mitochondrial Biogenesis in D-Galactose-Induced Aging Mice by Increasing Nrf2 and PGC-1α through the cAMP-CREB Pathway
por: Wang, Yu, et al.
Publicado: (2021)

Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra
por: Purves-Tyson, Tertia D, et al.
Publicado: (2012)

Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson’s substantia nigra
por: Ayton, Scott, et al.
Publicado: (2016)

Testosterone Upregulates the Expression of Mitochondrial ND1 and ND4 and Alleviates the Oxidative Damage to the Nigrostriatal Dopaminergic System in Orchiectomized Rats
por: Yan, Wensheng, et al.
Publicado: (2017)

The history of the research of iron in parkinsonian substantia nigra
por: Friedman, Andrzej, et al.
Publicado: (2012)

Isolated substantia nigra involvement in brainstem demyelination
por: Mahale, Rohan R., et al.
Publicado: (2015)

Nicotine impact on rat substantia nigra compacta
por: Elgayar, Sanaa A M, et al.
Publicado: (2021)

Enhanced training protects memory against amnesia produced by concurrent inactivation of amygdala and striatum, amygdala and substantia nigra, or striatum and substantia nigra
por: Salado-Castillo, Rigoberto, et al.
Publicado: (2011)

Anatomical and functional organization of the human substantia nigra and its connections
por: Zhang, Yu, et al.
Publicado: (2017)

Proteome analysis of human substantia nigra in Parkinson's disease
por: Werner, Cornelius J, et al.
Publicado: (2008)

Bidirectional Modulation of Substantia Nigra Activity by Motivational State
por: Rossi, Mark A., et al.
Publicado: (2013)

Operant Self-Stimulation of Dopamine Neurons in the Substantia Nigra
por: Rossi, Mark A., et al.
Publicado: (2013)

Epstein-Barr virus encephalitis with substantia nigra involvement
por: Çelik, Tamer, et al.
Publicado: (2015)

Mesencephalic origin of the rostral Substantia nigra pars reticulata
por: Madrigal, M. Pilar, et al.
Publicado: (2015)

Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction
por: Ohtomo, Gaku, et al.
Publicado: (2017)

Proliferation of Inhibitory Input to the Substantia Nigra in Experimental Parkinsonism
por: Faynveitz, Anna, et al.
Publicado: (2019)

Trehalose Neuroprotective Effects on the Substantia Nigra Dopaminergic Cells by Activating Autophagy and Non-canonical Nrf2 Pathways
por: Darabi, Shahram, et al.
Publicado: (2019)

Complementary Transcriptomic and Proteomic Analysis in the Substantia Nigra of Parkinson's Disease
por: Dong, Bao-hua, et al.
Publicado: (2021)

Dissociation between iron accumulation and ferritin upregulation in the aged substantia nigra: attenuation by dietary restriction
por: Walker, Thomas, et al.
Publicado: (2016)

Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson’s Disease
por: Zaman, Vandana, et al.
Publicado: (2022)

Complement activation in the Parkinson's disease substantia nigra: an immunocytochemical study
por: Loeffler, David A, et al.
Publicado: (2006)

Parcellation of the human substantia nigra based on anatomical connectivity to the striatum()
por: Chowdhury, Rumana, et al.
Publicado: (2013)

Tollip, an early regulator of the acute inflammatory response in the substantia nigra
por: Humbert-Claude, Marie, et al.
Publicado: (2016)

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
por: Dölle, Christian, et al.
Publicado: (2016)

Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra
por: Gao, Lin, et al.
Publicado: (2013)

Sex-Related Abnormalities in Substantia Nigra Lipids in Parkinson’s Disease
por: Seyfried, T. N., et al.
Publicado: (2018)

Genetic and constitutional factors are major contributors to substantia nigra hyperechogenicity
por: Vázquez-Costa, Juan F., et al.
Publicado: (2017)

Regional microglial activation in the substantia nigra is linked with fatigue in MS
por: Singhal, Tarun, et al.
Publicado: (2020)

The effect of titanium dioxide nanoparticles on mice midbrain substantia nigra
por: Heidari, Zahra, et al.
Publicado: (2019)

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease
por: Trist, Benjamin G., et al.
Publicado: (2019)

Angiotensin-II Modulates GABAergic Neurotransmission in the Mouse Substantia Nigra
por: Singh, Maibam R., et al.
Publicado: (2021)

Imaging of Substantia Nigra in Parkinson’s Disease: A Narrative Review
por: Feraco, Paola, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2kk7pf0632adbl3jnl4fh67gro