Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis

Skeletal muscle accounts for ~80% of insulin-stimulated glucose uptake. The Group I p21–activated kinase 1 (PAK1) is required for the non-canonical insulin-stimulated GLUT4 vesicle translocation in skeletal muscle cells. We found that the abundances of PAK1 protein and its downstream effector in mus...

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Detalles Bibliográficos
Autores principales: Merz, Karla E., Tunduguru, Ragadeepthi, Ahn, Miwon, Salunkhe, Vishal A., Veluthakal, Rajakrishnan, Hwang, Jinhee, Bhattacharya, Supriyo, McCown, Erika M., Garcia, Pablo A., Zhou, Chunxue, Oh, Eunjin, Yoder, Stephanie M., Elmendorf, Jeffrey S., Thurmond, Debbie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881144/
https://www.ncbi.nlm.nih.gov/pubmed/35222279
http://dx.doi.org/10.3389/fendo.2022.821849

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