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Solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors

The following is an overview of the treatment strategies and the prognostic factors to consider in the therapeutic choice of patients characterized by solitary colorectal liver metastasis. Liver resection is the only potential curative option; nevertheless, only 25% of the patients are considered to...

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Autores principales: Acciuffi, S., Meyer, F., Bauschke, A., Croner, R., Settmacher, U., Altendorf-Hofmann, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881245/
https://www.ncbi.nlm.nih.gov/pubmed/34914005
http://dx.doi.org/10.1007/s00432-021-03880-4
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author Acciuffi, S.
Meyer, F.
Bauschke, A.
Croner, R.
Settmacher, U.
Altendorf-Hofmann, A.
author_facet Acciuffi, S.
Meyer, F.
Bauschke, A.
Croner, R.
Settmacher, U.
Altendorf-Hofmann, A.
author_sort Acciuffi, S.
collection PubMed
description The following is an overview of the treatment strategies and the prognostic factors to consider in the therapeutic choice of patients characterized by solitary colorectal liver metastasis. Liver resection is the only potential curative option; nevertheless, only 25% of the patients are considered to be eligible for surgery. To expand the potentially resectable pool of patients, surgeons developed multidisciplinary techniques like portal vein embolization, two-stage hepatectomy or associating liver partition and portal vein ligation for staged hepatectomy. Moreover, mini-invasive surgery is gaining support, since it offers lower post-operative complication rates and shorter hospital stay with no differences in long-term outcomes. In case of unresectable disease, various techniques of local ablation have been developed. Radiofrequency ablation is the most commonly used form of thermal ablation: it is widely used for unresectable patients and is trying to find its role in patients with small resectable metastasis. The identification of prognostic factors is crucial in the choice of the treatment strategy. Previous works that focused on patients with solitary colorectal liver metastasis obtained trustable negative predictive factors such as presence of lymph-node metastasis in the primary tumour, synchronous metastasis, R status, right-sided primary colon tumor, and additional presence of extrahepatic tumour lesion. Even the time factor could turn into a predictor of tumour biology as well as further clinical course, and could be helpful to discern patients with worse prognosis.
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spelling pubmed-88812452022-03-02 Solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors Acciuffi, S. Meyer, F. Bauschke, A. Croner, R. Settmacher, U. Altendorf-Hofmann, A. J Cancer Res Clin Oncol Review – Clinical Oncology The following is an overview of the treatment strategies and the prognostic factors to consider in the therapeutic choice of patients characterized by solitary colorectal liver metastasis. Liver resection is the only potential curative option; nevertheless, only 25% of the patients are considered to be eligible for surgery. To expand the potentially resectable pool of patients, surgeons developed multidisciplinary techniques like portal vein embolization, two-stage hepatectomy or associating liver partition and portal vein ligation for staged hepatectomy. Moreover, mini-invasive surgery is gaining support, since it offers lower post-operative complication rates and shorter hospital stay with no differences in long-term outcomes. In case of unresectable disease, various techniques of local ablation have been developed. Radiofrequency ablation is the most commonly used form of thermal ablation: it is widely used for unresectable patients and is trying to find its role in patients with small resectable metastasis. The identification of prognostic factors is crucial in the choice of the treatment strategy. Previous works that focused on patients with solitary colorectal liver metastasis obtained trustable negative predictive factors such as presence of lymph-node metastasis in the primary tumour, synchronous metastasis, R status, right-sided primary colon tumor, and additional presence of extrahepatic tumour lesion. Even the time factor could turn into a predictor of tumour biology as well as further clinical course, and could be helpful to discern patients with worse prognosis. Springer Berlin Heidelberg 2021-12-16 2022 /pmc/articles/PMC8881245/ /pubmed/34914005 http://dx.doi.org/10.1007/s00432-021-03880-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review – Clinical Oncology
Acciuffi, S.
Meyer, F.
Bauschke, A.
Croner, R.
Settmacher, U.
Altendorf-Hofmann, A.
Solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors
title Solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors
title_full Solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors
title_fullStr Solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors
title_full_unstemmed Solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors
title_short Solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors
title_sort solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors
topic Review – Clinical Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881245/
https://www.ncbi.nlm.nih.gov/pubmed/34914005
http://dx.doi.org/10.1007/s00432-021-03880-4
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