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The efficacy of duloxetine depends on spinal cholinergic plasticity in neuropathic pain model rats
Antidepressants, such as duloxetine, are widely used to treat chronic pain, including neuropathic pain; however, their efficacy is unsatisfactory. In our previous studies, we showed that in a spinal nerve ligation (SNL) rat model, the descending noradrenergic inhibitory system, which involves in the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881419/ https://www.ncbi.nlm.nih.gov/pubmed/35243478 http://dx.doi.org/10.1016/j.ibneur.2022.02.004 |