Salt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injury

Receptor-interacting protein kinase 3 (RIPK3) functions as a central regulator of necroptosis, mediating signaling transduction to activate pseudokinase mixed lineage kinase domain-like protein (MLKL) phosphorylation. Increasing evidences show that RIPK3 contributes to the pathologies of inflammator...

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Detalles Bibliográficos
Autores principales: Huang, Dongxuan, Chen, Pengfei, Huang, Guoqing, Sun, Huimin, Luo, Xiaohua, He, Chaowen, Chen, Fei, Wang, Yong, Zeng, Changchun, Su, Lianhui, Zeng, Xiaobin, Lu, Jiachun, Li, Shiyue, Huang, Dongsheng, Gao, Hanchao, Cao, Mengtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881470/
https://www.ncbi.nlm.nih.gov/pubmed/35217652
http://dx.doi.org/10.1038/s41419-022-04633-y

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