AP-4-mediated axonal transport controls endocannabinoid production in neurons

The adaptor protein complex AP-4 mediates anterograde axonal transport and is essential for axon health. AP-4-deficient patients suffer from a severe neurodevelopmental and neurodegenerative disorder. Here we identify DAGLB (diacylglycerol lipase-beta), a key enzyme for generation of the endocannabi...

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Detalles Bibliográficos
Autores principales: Davies, Alexandra K., Alecu, Julian E., Ziegler, Marvin, Vasilopoulou, Catherine G., Merciai, Fabrizio, Jumo, Hellen, Afshar-Saber, Wardiya, Sahin, Mustafa, Ebrahimi-Fakhari, Darius, Borner, Georg H. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881493/
https://www.ncbi.nlm.nih.gov/pubmed/35217685
http://dx.doi.org/10.1038/s41467-022-28609-w

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