Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER(+) breast cancer

Extensive knowledge has been gained on the transcription network controlled by ERα, however, the mechanism underlying ESR1 (encoding ERα) expression is less understood. We recently discovered that the Hippo pathway is required for the proper expression of ESR1. YAP/TAZ are transcription coactivators...

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Detalles Bibliográficos
Autores principales: Ma, Shenghong, Tang, Tracy, Probst, Gary, Konradi, Andrei, Jin, Chunyu, Li, Fulong, Gutkind, J. Silvio, Fu, Xiang-Dong, Guan, Kun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881512/
https://www.ncbi.nlm.nih.gov/pubmed/35217640
http://dx.doi.org/10.1038/s41467-022-28691-0

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