Functionally additive fixed positive and negative charges in the CFTR channel pore control anion binding and conductance

Ion channels use charged amino-acid residues to attract oppositely charged permeant ions into the channel pore. In the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel, a number of arginine and lysine residues have been shown to be important for Cl(−) permeation. Among these,...

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Detalles Bibliográficos
Autores principales: Linsdell, Paul, Irving, Christina L., Cowley, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881524/
https://www.ncbi.nlm.nih.gov/pubmed/35101441
http://dx.doi.org/10.1016/j.jbc.2022.101659

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