Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies

Protein kinase inhibitors are amongst the most successful cancer treatments, but targetable kinases activated by genomic abnormalities are rare in T cell acute lymphoblastic leukemia. Nevertheless, kinases can be activated in the absence of genetic defects. Thus, phosphoproteomics can provide inform...

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Detalles Bibliográficos
Autores principales: Cordo’, Valentina, Meijer, Mariska T., Hagelaar, Rico, de Goeij-de Haas, Richard R., Poort, Vera M., Henneman, Alex A., Piersma, Sander R., Pham, Thang V., Oshima, Koichi, Ferrando, Adolfo A., Zaman, Guido J. R., Jimenez, Connie R., Meijerink, Jules P. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881579/
https://www.ncbi.nlm.nih.gov/pubmed/35217681
http://dx.doi.org/10.1038/s41467-022-28682-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881579/
https://www.ncbi.nlm.nih.gov/pubmed/35217681
http://dx.doi.org/10.1038/s41467-022-28682-1

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