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Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several multi-targeting agonists at GIPR, GLP-1R or GCGR, developed to maximize metabolic benefits with reduced side-effects, are in c...

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Detalles Bibliográficos
Autores principales:	Zhao, Fenghui, Zhou, Qingtong, Cong, Zhaotong, Hang, Kaini, Zou, Xinyu, Zhang, Chao, Chen, Yan, Dai, Antao, Liang, Anyi, Ming, Qianqian, Wang, Mu, Chen, Li-Nan, Xu, Peiyu, Chang, Rulve, Feng, Wenbo, Xia, Tian, Zhang, Yan, Wu, Beili, Yang, Dehua, Zhao, Lihua, Xu, H. Eric, Wang, Ming-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881610/ https://www.ncbi.nlm.nih.gov/pubmed/35217653 http://dx.doi.org/10.1038/s41467-022-28683-0

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