Cargando…

Multimerin-1 and cancer: a review

Multimerin-1 (MMRN1) is a platelet protein with a role in haemostasis and coagulation. It is also present in endothelial cells (ECs) and the extracellular matrix (ECM), where it may be involved in cell adhesion, but its molecular functions and protein–protein interactions in these cellular locations...

Descripción completa

Detalles Bibliográficos
Autor principal: Posner, Mareike G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881648/
https://www.ncbi.nlm.nih.gov/pubmed/35132992
http://dx.doi.org/10.1042/BSR20211248
_version_ 1784659520010584064
author Posner, Mareike G.
author_facet Posner, Mareike G.
author_sort Posner, Mareike G.
collection PubMed
description Multimerin-1 (MMRN1) is a platelet protein with a role in haemostasis and coagulation. It is also present in endothelial cells (ECs) and the extracellular matrix (ECM), where it may be involved in cell adhesion, but its molecular functions and protein–protein interactions in these cellular locations have not been studied in detail yet. In recent years, MMRN1 has been identified as a differentially expressed gene (DEG) in various cancers and it has been proposed as a possible cancer biomarker. Some evidence suggest that MMRN1 expression is regulated by methylation, protein interactions, and non-coding RNAs (ncRNAs) in different cancers. This raises the questions if a functional role of MMRN1 is being targeted during cancer development, and if MMRN1’s differential expression pattern correlates with cancer progression. As a result, it is timely to review the current state of what is known about MMRN1 to help inform future research into MMRN1’s molecular mechanisms in cancer.
format Online
Article
Text
id pubmed-8881648
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-88816482022-03-10 Multimerin-1 and cancer: a review Posner, Mareike G. Biosci Rep Cancer Multimerin-1 (MMRN1) is a platelet protein with a role in haemostasis and coagulation. It is also present in endothelial cells (ECs) and the extracellular matrix (ECM), where it may be involved in cell adhesion, but its molecular functions and protein–protein interactions in these cellular locations have not been studied in detail yet. In recent years, MMRN1 has been identified as a differentially expressed gene (DEG) in various cancers and it has been proposed as a possible cancer biomarker. Some evidence suggest that MMRN1 expression is regulated by methylation, protein interactions, and non-coding RNAs (ncRNAs) in different cancers. This raises the questions if a functional role of MMRN1 is being targeted during cancer development, and if MMRN1’s differential expression pattern correlates with cancer progression. As a result, it is timely to review the current state of what is known about MMRN1 to help inform future research into MMRN1’s molecular mechanisms in cancer. Portland Press Ltd. 2022-02-25 /pmc/articles/PMC8881648/ /pubmed/35132992 http://dx.doi.org/10.1042/BSR20211248 Text en © 2022 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Cancer
Posner, Mareike G.
Multimerin-1 and cancer: a review
title Multimerin-1 and cancer: a review
title_full Multimerin-1 and cancer: a review
title_fullStr Multimerin-1 and cancer: a review
title_full_unstemmed Multimerin-1 and cancer: a review
title_short Multimerin-1 and cancer: a review
title_sort multimerin-1 and cancer: a review
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881648/
https://www.ncbi.nlm.nih.gov/pubmed/35132992
http://dx.doi.org/10.1042/BSR20211248
work_keys_str_mv AT posnermareikeg multimerin1andcancerareview